{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T16:11:17Z","timestamp":1747152677974,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["836041002"],"award-info":[{"award-number":["836041002"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>We assessed the cost\u2010effectiveness and cost\u2010utility of therapeutic drug monitoring (TDM)\u2010guided mercaptopurine treatment compared with placebo in ulcerative colitis (UC) patients failing 5\u2010aminosalicylates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were gathered alongside the randomized controlled OPTIC trial (EudraCT: 2015\u2010005260\u201041). The evaluation was performed from a health care and societal perspective as cost\u2010effectiveness and cost\u2010utility analyses with a time horizon of one year. Volumes and costs of in\u2010hospital care, out\u2010of\u2010hospital care, out\u2010of\u2010pocket expenses and productivity loss were assessed. The main outcomes were the extra costs per additional patient who achieved clinical remission and endoscopic improvement at 52\u00a0weeks (responders) and extra costs per quality\u2010adjusted life\u2010year (QALY) gained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 59 patients were randomized to the intervention (<jats:italic>n<\/jats:italic>\u00a0=\u00a029) and control (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) group. Non\u2010significant differences in costs were \u20ac63 (\u2212\u20ac1267 to \u20ac1434; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.93) in favour of placebo from a health care perspective and \u2212\u20ac742 (\u2212\u20ac3683 to \u20ac2016; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.64) in favour of mercaptopurine from a societal perspective. The higher proportion of responders and a non\u2010significant QALY difference of 0.0475 (\u22120.024\u20130.117) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.184) favouring patients on mercaptopurine treatment resulted in \u20ac165 extra costs per additional responder and \u20ac1326 extra costs per QALY gained from a health care perspective. From a societal perspective, dominance over placebo was observed with cost savings of \u20ac1937 per additional responder and \u20ac15,621 per QALY gained. The probability of optimised mercaptopurine treatment being cost\u2010effective was 0.80 at a willingness to pay per additional QALY of \u20ac20,000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TDM\u2010based mercaptopurine treatment in UC patients failing 5\u2010aminosalicylates is a cost\u2010effective strategy from a societal perspective.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12661","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T06:40:32Z","timestamp":1728888032000},"page":"1256-1265","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2010effectiveness and cost\u2010utility of optimized mercaptopurine treatment versus placebo in ulcerative colitis patients: The randomized controlled OPTIC trial"],"prefix":"10.1002","volume":"12","author":[{"given":"Mark","family":"L\u00f6wenberg","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute Amsterdam University Medical Center VU University Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marit","family":"van Barreveld","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science Amsterdam University Medical Center  Amsterdam The Netherlands"},{"name":"Methodology Amsterdam Public Health University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9547-1627","authenticated-orcid":false,"given":"Adriaan","family":"Volkers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"van Gennep","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolijn","family":"Duijvestein","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboudumc  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan A.","family":"van Bodegraven","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zuyderland Medical Centre and Maastricht University Medical Center  Sittard The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1792-2533","authenticated-orcid":false,"given":"Melanie S.","family":"Hulshoff","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen M.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology OLVG  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"van Asseldonk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Noordwest Ziekenhuisgroep  Alkmaar The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"West","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Franciscus Gasthuis  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert","family":"D\u2019Haens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute Amsterdam University Medical Center VU University Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanne","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute Amsterdam University Medical Center VU University Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel G. 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