{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:02:44Z","timestamp":1789718564091,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Individuals carrying a germline\n                      <jats:italic>CDKN2A<\/jats:italic>\n                      pathogenic variant (PV) are at a high risk of developing pancreatic ductal adenocarcinoma. Risk stratification could allow tailored surveillance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To develop a Fine\u2010Gray prediction model for the risk of PDAC in carriers of a\n                      <jats:italic>CDKN2A<\/jats:italic>\n                      PV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from two large Dutch pancreatic cancer surveillance programs were used. A limited set of predictor variables were selected bsased on previous literature and the clinical expertise of the study group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 506\n                      <jats:italic>CDKN2A<\/jats:italic>\n                      PV carriers were included, among whom we showed a substantial lifetime risk of PDAC (23%). The model identifies having a first\u2010degree relative with PDAC (\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a00.7256) and a history of smoking (\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a00.4776) as significant risk factors. However, the model shows limited discrimination (c\u2010statistic 0.64) and calibration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our study highlights the high lifetime risk of PDAC in carriers of a\n                      <jats:italic>CDKN2A<\/jats:italic>\n                      PV. While identifying significant risk factors such as family history of PDAC and smoking, our prediction model shows limited precision, highlighting the need for additional factors such as biomarkers to improve its clinical utility for tailored surveillance of high\u2010risk individuals.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12662","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T07:10:24Z","timestamp":1730963424000},"page":"1399-1403","source":"Crossref","is-referenced-by-count":7,"title":["Pancreatic cancer surveillance: Risk stratification of individuals with a germline\n                    <i>CDKN2A<\/i>\n                    pathogenic variant"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-6725","authenticated-orcid":false,"given":"Derk C. F.","family":"Klatte","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4205-6860","authenticated-orcid":false,"given":"Jihane","family":"Meziani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djuna L.","family":"Cahen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merel","family":"van Diepen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco J.","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E.","family":"van Leerdam","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Gastrointestinal Oncology Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Dutch Pancreatic Cancer Surveillance Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_2_10_2_1","article-title":"Pancreatic cancer surveillance in carriers of a germline CDKN2A pathogenic variant: yield and outcomes of a 20\u2010year prospective follow\u2010up","author":"Klatte DCF","year":"2022","journal-title":"J Clin Oncol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.02.032"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010323611"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ede.0b013e3181a39056"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.11.025"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz032"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxt059"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2022.03.021"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.04.1342"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.12662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T16:03:44Z","timestamp":1764518624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.12662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/ueg2.12662"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.12662","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]}}}