{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:07:04Z","timestamp":1787580424381,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>People with inflammatory bowel disease (IBD) often experience pain, fatigue and bowel incontinence and are at an increased risk of anxiety and depression. Our aim was to assess the impact of these symptoms on health\u2010related quality of life (QoL) in IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the IBD\u2010BOOST survey, over 26,000 people with IBD across the UK were approached; 8486 participant\u2010completed surveys were returned. Participants' QoL was measured using the EQ\u20105D\u20105L questionnaire and their QoL was calculated on a scale ranging from 1 (perfect health) to \u22120.594 (worst health). Item non\u2010response was imputed. Stages of linear regression models assessed the associations of symptoms with QoL controlling for IBD type, socio\u2010demographic characteristics, co\u2010morbidities and, in further analysis, for IBD activity and IBD control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The EQ\u20105D\u20105L questionnaire was fully completed by 8093 (95.4%) participants (mean age of 50\u00a0years [SD 15]; 49% with Crohn's disease). The mean QoL was 0.76 (SD 0.23). From the three IBD\u2010related symptoms, pain was associated with the largest QoL decrement (\u22120.159), followed by fatigue (\u22120.140) and bowel incontinence (\u22120.048). Co\u2010occurrence of pain and fatigue further reduced QoL. Clear graded associations were observed between symptom severity and QoL decrements (all trend\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Depression and anxiety were also associated with significant QoL decrements (\u22120.102 and \u22120.110 for moderate\u2010to\u2010severe anxiety and moderately severe depression, respectively). Worse IBD control and higher IBD activity were associated with lower QoL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We report strong associations between symptoms of pain, fatigue, bowel incontinence, anxiety, depression, and their severity and reduced QoL in IBD. These estimates could inform future IBD management interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12668","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T10:53:59Z","timestamp":1729335239000},"page":"364-375","source":"Crossref","is-referenced-by-count":19,"title":["Impact of pain, fatigue and bowel incontinence on the quality of life of people living with inflammatory bowel disease: A UK cross\u2010sectional survey"],"prefix":"10.1002","volume":"13","author":[{"given":"Chris","family":"Roukas","sequence":"first","affiliation":[{"name":"Health Economics and Policy Research Unit Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Miller","sequence":"additional","affiliation":[{"name":"Pragmatic Clinical Trials Unit Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fionn","family":"Cl\u00e9irigh B\u00fcttner","sequence":"additional","affiliation":[{"name":"Pragmatic Clinical Trials Unit Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hamborg","sequence":"additional","affiliation":[{"name":"Pragmatic Clinical Trials Unit Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imogen","family":"Stagg","sequence":"additional","affiliation":[{"name":"Faculty of Nursing Midwifery and Palliative Care King's College London  London UK"},{"name":"IBD Unit St Mark's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Hart","sequence":"additional","affiliation":[{"name":"IBD Unit St Mark's Hospital  London 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