{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:09:17Z","timestamp":1787504957210,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01DK130113"],"award-info":[{"award-number":["U01DK130113"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007827","name":"American College of Gastroenterology","doi-asserted-by":"publisher","award":["Junior Faculty Development Award"],"award-info":[{"award-number":["Junior Faculty Development Award"]}],"id":[{"id":"10.13039\/100007827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,11]]},"abstract":"Abstract<\/jats:title>\n \n Background & Aims<\/jats:title>\n Paracentesis is commonly used to manage patient discomfort due to ascites. The relationship between ascites pressure, ascites volume, and patient discomfort has not been elucidated.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We prospectively enrolled adult patients with non\u2010malignant ascites undergoing outpatient therapeutic paracenteses from 2021 to 2024 at a tertiary care hospital. Patients completed a validated symptom questionnaire (ASI\u20107, maximum score 35) before, immediately after, and 1\u00a0week after paracentesis. An open\u2010ended manometer was used to measure ascites pressure at the beginning and end of paracentesis. Mixed effect linear regression was performed to evaluate the relationships between patient characteristics, pressure, volume, and symptoms.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and fifty paracentesis procedures among 48 unique patients with an average Model for End Stage Liver Disease\u2010Sodium 3.0 of 16.7 were included. An average of 6.5\u00a0L was drained, which reduced abdominal pressure from a mean of 13.7 to 6.0\u00a0cm H\n 2<\/jats:sub>\n O (10.1 to 4.4\u00a0mmHg,\n p<\/jats:italic>\n \u00a0<\u00a00.001) and mean symptom score from 22.6 to 6.5 (\n p<\/jats:italic>\n \u00a0<\u00a00.001). Regression models identified that symptoms and abdominal pressure linearly correlated above a pressure of 6\u00a0cm H\n 2<\/jats:sub>\n O or ASI\u20107 score of 16 (\n p<\/jats:italic>\n \u00a0<\u00a00.01). Taller patients required about 670\u00a0ml additional drainage per inch above the cohort mean height (5\u20328\u2033) to achieve the same symptom relief.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Pressure measured at the bedside can be used to explore changes in abdominal pressure during paracentesis. Pressure, volume, and patient level factors such as height contribute to patient symptoms but cannot fully explain discomfort associated with ascites and relief after paracentesis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ueg2.12675","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T12:16:45Z","timestamp":1728389805000},"page":"1222-1229","source":"Crossref","is-referenced-by-count":3,"title":["The physiological determinants of symptom burden in cirrhosis with ascites"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9749-5334","authenticated-orcid":false,"given":"Nikhilesh R.","family":"Mazumder","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan Ann Arbor Michigan USA"},{"name":"Gastroenterology Section VA Ann Arbor Healthcare System Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-7389","authenticated-orcid":false,"given":"Filip","family":"Jezek","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sardar","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0839-1515","authenticated-orcid":false,"given":"Elliot B.","family":"Tapper","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan Ann Arbor Michigan USA"},{"name":"Gastroenterology Section VA Ann Arbor Healthcare System Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5811-6845","authenticated-orcid":false,"given":"Anna S.","family":"Lok","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010022\u201007454\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29756"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2013.20"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2018.18"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016\u20105085(88)90691\u20109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2021.04.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080202"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31884"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.024"},{"key":"e_1_2_10_12_1","unstructured":"Optn. Guidance to Liver Transplant Programs and the National Liver Review Board for: adult MELD exception review."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32598"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.12675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T23:56:53Z","timestamp":1732147013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.12675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ueg2.12675"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.12675","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,8]]}}}