{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:34:03Z","timestamp":1789569243019,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["53589363"],"award-info":[{"award-number":["53589363"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Up to 15% of ulcerative colitis (UC) patients with an ileo\u2010anal pouch will develop chronic or antibiotic refractory pouchitis. We aimed to evaluate the efficacy and safety of tofacitinib in these refractory patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective single center study, adult UC patients with chronic or antibiotic refractory pouchitis (pouchitis disease activity index [PDAI]\u00a0\u2265\u00a07) were treated with tofacitinib 10\u00a0mg twice daily for 8\u00a0weeks. Clinical, biochemical, endoscopic and histologic disease activity was assessed at baseline and at week 8. The primary endpoint was the proportion of patients achieving clinical remission (PDAI\u00a0&lt;\u00a07 and a reduction of \u22653 points from baseline) or clinical response (decrease \u22652 points from baseline).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients were included and treated with tofacitinib. After 8\u00a0weeks, 31% achieved PDAI\u2010defined remission (4\/13) and 54% achieved response (7\/13). Both the total PDAI score (11 [interquartile range 9\u201312.75] vs. 8 [4.5\u20139.75], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.033) and the clinical PDAI subscore (4 [3\u20134] vs. 2 [0.25\u20133.75], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014) decreased significantly from baseline compared to week 8 or early withdrawal, respectively. We did not observe a change in endoscopic or histological PDAI subscores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this pilot study, clinical remission in patients with chronic pouchitis was achieved in 31% of patients after 8\u00a0weeks of treatment with tofacitinib. Total and clinical PDAI dropped significantly compared with baseline, but we did not observe a significant change in endoscopic or histologic disease activity. Presumably, a treatment duration of 8\u00a0weeks is insufficient to induce mucosal healing in these refractory patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12683","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T07:39:52Z","timestamp":1738568392000},"page":"201-209","source":"Crossref","is-referenced-by-count":7,"title":["Tofacitinib for the treatment of chronic pouchitis: A pilot study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-9798","authenticated-orcid":false,"given":"Djuna C.","family":"de Jong","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier","family":"Goetgebuer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart L. M.","family":"M\u00fcskens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Andra","family":"Neefjes\u2010Borst","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina B.","family":"Gecse","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"L\u00f6wenberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research Amsterdam University Medical Center University of Amsterdam  Amsterdam The 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