{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:22:42Z","timestamp":1792174962475,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010721","name":"Ironwood Pharmaceuticals, Incorporated","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007343","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007343","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prevalence of disorders of the gut\u2010brain interaction (DGBI) among people with obesity in the general population is unknown. Our aim was to assess the prevalence of DGBI among obese subjects in the general population in comparison with normal or overweight subjects, as well as exploring factors associated with DGBI in obesity in Europe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included subjects who completed the internet\u2010based survey of the Rome Foundation Global Epidemiology study in 11 European countries. Obesity was defined as a BMI&gt;30\u00a0kg\/m<jats:sup>2<\/jats:sup> and participants were divided into three classes: 1: BMI 30 to &lt;35\u00a0kg\/m<jats:sup>2<\/jats:sup>, 2: BMI 35 to &lt;40\u00a0kg\/m<jats:sup>2<\/jats:sup>, and 3: BMI 40\u00a0kg\/m<jats:sup>2<\/jats:sup> or higher. The prevalence of symptoms compatible with DGBI was reported and compared between obese and normal or overweight (BMI between 18.5 and &lt;30\u00a0kg\/m<jats:sup>2<\/jats:sup>) participants. Factors potentially associated with DGBI and obesity including demographics, psychological distress (PHQ\u20104), non\u2010GI somatic symptoms (PHQ\u201312), quality of life (PROMIS\u201010), healthcare access, medication and food consumption were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 20,117 participants in our analysis. The prevalence of obesity was 17.8% (95% CI 17.3, 18.4), with 12.6%, 3.7% and 1.6% in obesity classes 1, 2 and 3, respectively. The prevalence of any DGBI was 44.2% in the obese group versus 39.6% in the normal or overweight group (OR\u00a0=\u00a01.20 (1.12, 1.30)), with all DGBI being more prevalent in the obese versus normal or overweight group, with the exception for functional constipation where the opposite pattern was seen. Female sex, higher level of psychological distress and more severe non\u2010GI somatic symptoms were seen in the group with DGBI associated with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Symptoms compatible with DGBI are common among European people with obesity in the general population and are linked with certain demographic and disease\u2010related factors. This should be acknowledged in the management of patients with obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.12700","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T04:10:14Z","timestamp":1744085414000},"page":"917-928","source":"Crossref","is-referenced-by-count":9,"title":["Disorders of the gut\u2010brain interaction among European people with obesity: Prevalence and burden of compatible symptoms"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-1540","authenticated-orcid":false,"given":"Chlo\u00e9","family":"Melchior","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Univ Rouen Normandie INSERM, ADEN UMR1073 \u201cNutrition, Inflammation and Microbiota\u2010Gut\u2010Brain Axis\u201d CHU Rouen, CIC\u2010CRB 1404  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0078-3063","authenticated-orcid":false,"given":"J\u00f3hann P","family":"Hreinsson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) Department of Chronic Diseases, Metabolism and Aging (CHROMETA) KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-1115","authenticated-orcid":false,"given":"Jutta","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Israelitic Hospital Hamburg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qasim","family":"Aziz","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience Surgery and Trauma Blizard Institute Wingate Institute of Neurogastroenterology Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur S","family":"Palsson","sequence":"additional","affiliation":[{"name":"Center for Functional GI and Motility Disorders University of North Carolina\u2010Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikant I","family":"Bangdiwala","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact, and Population Health Research Institute McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-3689","authenticated-orcid":false,"given":"Ami D","family":"Sperber","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Simr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Center for Functional GI and Motility Disorders University of North Carolina\u2010Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marc","family":"Sabat\u00e9","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology H\u00f4pital Avicenne AP\u2010HP Sorbonne Paris Nord  Bobigny France"},{"name":"INSERM U987 Pathophysiology and Clinical Pharmacology of Pain H\u00f4pital Ambroise Par\u00e9  Boulogne\u2010Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO European Regional Obesity Report.2022. 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