{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:59:54Z","timestamp":1784829594349,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic esophagitis (EoE) is a chronic, inflammatory disease of the esophagus. Chronic inflammation has been linked to cancer development. We aimed to study the potential association between EoE and later cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this nationwide population\u2010based cohort study, we identified 1580 individuals with EoE diagnosed between 1990\u20132017 through Sweden's 28 pathology departments. Up to five general population reference individuals were matched on age and sex (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07533). A Cox regression analysis estimated adjusted hazard ratios (aHRs) for cancer up until December 31, 2020. To reduce potential intrafamilial confounding, we also compared EoE individuals with their unaffected siblings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median follow\u2010up of 7\u00a0years, 47 individuals with EoE (3.9\/1000\u00a0person\u2010years) developed cancer versus 183 (3.2\/1000\u00a0person\u2010years) reference individuals. This corresponded to a non\u2010significant aHR of 1.11 (95% CI\u00a0=\u00a00.80\u20131.53). Incidence rates were independent of budesonide and proton\u2010pump inhibitor use. Individuals with EoE however did have an increased risk of esophageal cancer where two EoE versus one reference individual were diagnosed (aHR\u00a0=\u00a025.20; 95% CI\u00a0=\u00a02.28\u2013278.80), and also Barrett's esophagus risk was also increased in EoE (HR\u00a0=\u00a018.18; 95% CI\u00a0=\u00a06.75\u201348.95). Non\u2010esophageal gastrointestinal (GI) cancer occurred in 11 EoE versus 24 reference individuals: aHR\u00a0=\u00a02.03 (95% CI\u00a0=\u00a00.99\u20134.18). We found no increased risk of cancers from the skin (EoE\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010), lung (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a00), breast (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04), or blood (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a00). Sibling analyses supported these findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We did not find any overall association between EoE and cancer development. EoE was associated with esophageal cancer, but this was very rare with wide confidence interval and few cases therefore we urge caution with generalization of these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12713","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T08:09:52Z","timestamp":1732090192000},"page":"1378-1387","source":"Crossref","is-referenced-by-count":5,"title":["Risk of Cancer Diagnosis in Patients With Eosinophilic Esophagitis Using a Nationwide Swedish Population Cohort"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2171-4769","authenticated-orcid":false,"given":"Amiko M.","family":"Uchida","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-9016","authenticated-orcid":false,"given":"Sophia S.","family":"Schuman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Pyne","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Peterson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Carlson","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Group Department of Medical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Garber","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Roelstraete","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Pediatrics \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Department of Medicine Celiac Disease Center Columbia University College of Physicians and Surgeons  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.008"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388\u2010022\u201000926\u20105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.48101\/ujms.v126.7688"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.48101\/ujms.v126.7687"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28832"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101602237"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010022\u201000720\u20102"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2023.08.005"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201013\u20100196"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.104"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201018\u20100494"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.11.014"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1393134"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.024"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.02.012"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox050"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13537"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010009\u20109350\u2010y"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010017\u20100316\u20101"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/140349489001800209"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u201011\u2010450"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010016\u20100117\u2010y"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802247664"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010019\u201000511\u20108"},{"key":"e_1_2_12_27_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_12_28_1","unstructured":"T.Therneau \u201c_A Package for Survival Analysis in R_. 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