{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:27:49Z","timestamp":1790116069143,"version":"4.0.1"},"reference-count":89,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Endoscopic retrograde cholangiopancreatography (ERCP) is becoming more common than first\u2010line therapy for pancreaticobiliary duct disorders. However, post\u2010ERCP pancreatitis is the most common complication of ERCPs, and affects about 10% of cases. In this review, we provide an overview of the mechanisms purported to cause post\u2010ERCP pancreatitis as well as associated risk factors. We discuss measures that are in practice for post\u2010ERCP pancreatitis pharmaco\u2010prophylaxis, along with advances in the pipeline. We emphasize that there is still a pressing need to narrow the incidence of post\u2010ERCP pancreatitis and that a mechanistic approach may reveal the greatest benefit from utilizing a combination of targets.<\/jats:p>","DOI":"10.1002\/ueg2.12732","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T10:08:51Z","timestamp":1734948531000},"page":"78-85","source":"Crossref","is-referenced-by-count":16,"title":["Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis: Novel Mechanisms and Prevention by Drugs"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8909-1951","authenticated-orcid":false,"given":"Venkata S.","family":"Akshintala","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Johns Hopkins Medical Institutions  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibadat S.","family":"Boparai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Johns Hopkins Medical Institutions  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique T.","family":"Barakat","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Pediatrics School of Medicine Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-1308","authenticated-orcid":false,"given":"Sohail Z.","family":"Husain","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Pediatrics School of Medicine Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.03.023"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101220\u20102242"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102012\u2010302779"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016\u20105107(91)70740\u20102"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.06.045"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619834839"},{"key":"e_1_2_5_8_1","first-page":"162","article-title":"Mechanisms Involved in the Onset of Post\u2010ERCP Pancreatitis","volume":"3","author":"Pezzilli R.","year":"2002","journal-title":"Journal of Periodontology"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2002.118964"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u2010102250"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751\u20102980.13208"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00012.2012"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf01318124"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010001\u20109073\u2010y"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091500311"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2006.00380.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.07.014"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010020\u201008136\u20109"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000049"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016\u20105107(03)02530\u20106"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.5"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vgie.2020.04.015"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1443\u20101661.2000.00019.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010010\u20100268\u20107"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016\u20105107(99)70444\u2010x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.01.018"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.07.006"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496349"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd009662.pub3"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u20101001443"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.117550"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.06.036"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci64931"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2022.404"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201060312\u20102"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.101"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.148551"},{"key":"e_1_2_5_38_1","first-page":"523","article-title":"Central and Peripheral Neural Control of Pancreatic Exocrine Secretion","volume":"52","author":"Niebergall\u2010Roth E.","year":"2001","journal-title":"Journal of Physiology & Pharmacology"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m200878200"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35951"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.08.045"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010198002000\u201000010"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1091\u2010255x(01)80059\u20107"},{"key":"e_1_2_5_44_1","volume-title":"Presented at PancreasFest, Pittsburgh","author":"Thiruvengadam N.","year":"2019"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.031905.161253"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.07.036"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.051"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.08.006"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2022.07.008"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016\u20105107(02)70112\u20100"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102000\u2010138"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102002\u201023630"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102006\u2010925447"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u20101008945"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016\u20105107(04)02169\u20108"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2001.03594.x"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047\u2010783x\u201019\u201026"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2014.11.005"},{"key":"e_1_2_5_59_1","article-title":"Development and Validation of a Machine Learning\u2010Based, Point\u2010of\u2010Care Risk Calculator for Post\u2010ERCP Pancreatitis and Prophylaxis Selection","author":"Brenner T.","year":"2024","journal-title":"Gastrointestinal Endoscopy"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.12.010"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12534"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(21)00170\u20109"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101377875"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.10.005"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12117"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00568201"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100773.1985.tb00052.x"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.048"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1111103"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.11.013"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.08.050"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.05.026"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.06.007"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617707864"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2202884"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00057-1"},{"key":"e_1_2_5_77_1","volume-title":"Pancreapedia: Exocrine Pancreas Knowledge Base","author":"Elmunzer B. J.","year":"2015"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010020\u201000796\u2010w"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018\u2010199512050\u201000006"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010200059020\u201000021"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2021.265"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0025\u20106196(12)61226\u20109"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.11.038"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102013\u2010306564"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0000000000001312"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577\u2010023\u201000963\u2010x"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58091261"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.30.5.602"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0b013e3182152eb6"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2022.25"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.12732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T13:41:50Z","timestamp":1746538910000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.12732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":89,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/ueg2.12732"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.12732","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]}}}