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Recent advancements in its management have primarily focussed on the development of early phase medical interventions targeting inflammatory pathways, optimisation of supportive treatment (including fluid resuscitation, pain management and nutritional management), appropriate use of antibiotics, implementation of minimally invasive interventions for infected necrosis, and the necessity of follow\u2010up for long\u2010term complications. These advancements have significantly improved personalised management and overall outcomes of acute pancreatitis. Despite these efforts, early\u2010phase medical interventions to mitigate disease progression are still lacking and acute pancreatitis remains a heterogeneous disease. Future research and clinical trials are imperative to further optimise current strategies and develop new therapeutic approaches. This review presents an evidence\u2010based approach to the management of acute pancreatitis, highlighting recent developments.<\/jats:p>","DOI":"10.1002\/ueg2.12743","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T11:44:49Z","timestamp":1736768689000},"page":"97-106","source":"Crossref","is-referenced-by-count":87,"title":["Acute Pancreatitis: An Update of Evidence\u2010Based Management and Recent Trends in Treatment Strategies"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7295-8927","authenticated-orcid":false,"given":"Astrid","family":"Beij","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam Gastroenterology Endocrinology Metabolism Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Department of Research and Development St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5591-0499","authenticated-orcid":false,"given":"Robert C.","family":"Verdonk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1218-2883","authenticated-orcid":false,"given":"Hjalmar C.","family":"van Santvoort","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Antonius Hospital  Nieuwegein the Netherlands"},{"name":"Department of Surgery University Medical Centre Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-9541","authenticated-orcid":false,"given":"Enrique","family":"de\u2010Madaria","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dr Balmis General University Hospital\u2010ISABIAL  Alicante Spain"},{"name":"Department of Clinical Medicine Miguel Hernandez University  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-019X","authenticated-orcid":false,"given":"Rogier P.","family":"Voermans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam Gastroenterology Endocrinology Metabolism Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.09.043"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102012\u2010302779"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000002766"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12464"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0000000000002249"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i18.2187"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(08)60207\u2010x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520892"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010019\u201005883\u20109"},{"key":"e_1_2_8_12_1","article-title":"Does Fishoil Infusion Reduce Severe Complications in Predicted Severe Acute Pancreatitis?","author":"Nagelhout A.","year":"2021","journal-title":"ISCRTN"},{"key":"e_1_2_8_13_1","unstructured":"\u201cProphylactic Tributyrin Supplementation in Acute Pancreatitis; a Phase IIa (Proof of Concept) Double\u2010Blind Randomized Placebo\u2010Controlled Food Supplement Trial.\u201d (2023) https:\/\/clinicaltrials.gov\/study\/NCT06147635"},{"key":"e_1_2_8_14_1","volume-title":"Patients With Acute Pancreatitis","author":"Phase I. 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