{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:21:13Z","timestamp":1793805673108,"version":"4.6.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and aims<\/jats:title>\n Probe\u2010based confocal endomicroscopy (pCLE) allows real\u2010time microscopic visualization of the intestinal mucosa surface layers. Despite remission achieved through anti\u2010tumor necrosis factor or vedolizumab therapy, anomalies in the intestinal epithelial barrier are observed in inflammatory bowel disease (IBD) patients. Our study aimed to assess these abnormalities in non\u2010IBD individuals and compare them with IBD patients in endoscopic remission to identify the associated factors.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The study involved 84 patients, 40 with IBD under biologic therapy for over 6\u00a0months and in endoscopic remission, and 44 without IBD or irritable bowel syndrome (IBS) undergoing colorectal screening colonoscopy. White light endoscopy and probe\u2010based confocal laser endomicroscopy were performed in the ileum, right colon, transverse colon, left colon, and rectum. Demographic, clinical, biological, and morphological factors were examined.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n pCLE revealed abnormalities in both non\u2010IBD individuals and those with IBD in endoscopic remission, such as fluorescein leakage, blood vessel dilatation, and hypervascularization across all segments, as well as epithelial gaps in the ileum, and crypt dilatation in the colon. Comparing the two groups, IBD patients exhibited slightly more gaps in the ileum, increased fluorescein leakage in the transverse colon, and fewer vessel dilatation in the transverse colon. Abnormalities were more frequent in cases of hypertension (\n p<\/jats:italic>\n \u00a0=\u00a00.03), dyslipidemia (\n p<\/jats:italic>\n \u00a0=\u00a00.02), female gender (\n p<\/jats:italic>\n \u00a0=\u00a00.02), selective serotonin reuptake inhibitor (\n p<\/jats:italic>\n \u00a0=\u00a00.03), and family history of IBD (\n p<\/jats:italic>\n \u00a0=\u00a00.04) or colorectal cancer (\n p<\/jats:italic>\n \u00a0=\u00a00.03).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Confocal endomicroscopy abnormalities are present in both non\u2010IBD individuals undergoing colorectal cancer screening colonoscopy as in those with IBD in endoscopic remission. Further research is needed to understand the pathophysiological mechanisms of these abnormalities and their clinical impact.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ueg2.12756","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T06:40:06Z","timestamp":1738046406000},"page":"576-585","source":"Crossref","is-referenced-by-count":4,"title":["Confocal Endomicroscopy Intestinal Epithelial Barrier Abnormalities in Individuals Without Documented Gastro\u2010Intestinal Disease"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-2708","authenticated-orcid":false,"given":"Thanh\u2010Hien","family":"Trieu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology CHU Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1859-7146","authenticated-orcid":false,"given":"Sophie","family":"Vieujean","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Delhougne","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Seidel","sequence":"additional","affiliation":[{"name":"Department of Statistics CHU Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1287-7075","authenticated-orcid":false,"given":"Edouard","family":"Louis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Loly","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.34"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i5.1165"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13071230"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010331579"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.06.021"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22907"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102011\u2010300695"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3462"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjac190.0450"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad066"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101119\u20106327"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjaa255"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs20180087"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189310"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20993"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00063.2019"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1554"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010325181"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.100"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1203502"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010018\u20105006\u20105"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010020\u201006702\u20108"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010324598"}],"container-title":["United 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