{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:04:32Z","timestamp":1780441472024,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background & Aims<\/jats:title>\n Venous thromboembolism (VTE) is a recognized complication of acutely ill patients, but its incidence and risk factors in those with cirrhosis are uncertain.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We retrospectively studied a consecutive cohort of cirrhosis patients non\u2010electively admitted to our medical unit to determine the rates of symptomatic VTE during hospitalization. Firstly, we explored associations with baseline, clinical and laboratory characteristics using logistic regression. Secondly, we developed a clinical prediction model that could predict the risk of in\u2010hospital VTE.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We included 687 patients (median age 61\u00a0years old; 68% male; Child\u2013Pugh A\/B\/C, 13%\/40%\/47%). During hospitalization, 34 patients (4.9%) experienced VTE. Multivariate analysis showed that male sex (OR: 2.56,\n p<\/jats:italic>\n \u00a0=\u00a00.05), AKI (OR: 3.1,\n p<\/jats:italic>\n \u00a0=\u00a00.001), bacterial infections (OR: 2.6,\n p<\/jats:italic>\n \u00a0=\u00a00.008), Pugh score (OR: 1.6.\n p<\/jats:italic>\n \u00a0<\u00a00.001), family history of thrombosis (OR: 3.1,\n p<\/jats:italic>\n \u00a0=\u00a00.04), reduced mobility (OR: 4.6,\n p<\/jats:italic>\n \u00a0<\u00a00.001), and C\u2010reactive protein (OR: 1.1,\n p<\/jats:italic>\n \u00a0=\u00a00.005) were independent predictors of VTE. We combined these variables in a prediction model (\n Ci<\/jats:italic>\n rrhosis\n Thro<\/jats:italic>\n mbosis\n Model<\/jats:italic>\n ) that accurately discriminated between high\u2010 and low\u2010risk patients. The AUROC of CiThroModel was significantly higher than that of Padua prediction score (0.882 vs. 0.742). After validating the CiThroModel using bootstrapping, the adjusted model maintained optimal discrimination ability (0.862) and calibration. The adjusted formula to calculate the in\u2010hospital risk of VTE was \u22129.00\u00a0+\u00a00.82 [Male sex]\u00a0+\u00a01.14 [AKI]\u00a0+\u00a00.98 [Infection]\u00a0+\u00a00.48\u00a0*\u00a0Child Pugh score\u00a0+\u00a01.14 [VTE family history]\u00a0+\u00a01.54 [Reduced mobility] + 0.15\u00a0*\u00a0PCR\/10.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The CiThroModel seems a valuable tool for identifying hospitalized patients with cirrhosis at risk of VTE (\n https:\/\/majinzin.shinyapps.io\/vterisk\/<\/jats:ext-link>\n ).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ueg2.12758","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T08:03:49Z","timestamp":1737619429000},"page":"728-737","source":"Crossref","is-referenced-by-count":2,"title":["CiThroModel Improves Prediction of Symptomatic Venous Thromboembolism in Hospitalized Patients With Cirrhosis Without Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-7178","authenticated-orcid":false,"given":"Alberto","family":"Zanetto","sequence":"first","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology University of Padova Padova Italy"},{"name":"Gastroenterology and Multivisceral Transplant Unit Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Vitale","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology University of Padova Padova Italy"},{"name":"Hepatobiliary Surgery and Liver Transplantation Unit Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Pelizzaro","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology University of Padova Padova Italy"},{"name":"Gastroenterology and Multivisceral Transplant Unit Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Simeon","sequence":"additional","affiliation":[{"name":"Medical Statistics Unit University \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Campello","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED) University of Padova Padova Italy"},{"name":"First Chair of Internal Medicine and Thrombotic and Haemorrhagic Disease Unit Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8148-3769","authenticated-orcid":false,"given":"Laura","family":"Turco","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit for the Treatment of Severe Organ Failure IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna 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