{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:21:41Z","timestamp":1784820101374,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emerging evidence suggests that individuals who recover from acute pancreatitis may face a significant risk of mortality during the early post\u2010discharge period. Despite these concerns, comprehensive population\u2010based studies on this issue are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To study in\u2010hospital and post\u2010discharge mortality in patients with acute pancreatitis and how it has changed over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a Danish nationwide population\u2010based cohort study, we included all adults discharged after an incident episode of acute pancreatitis between 2002 and 2017. For each patient, five individuals from the general population, matched by age and sex, were selected as controls. We used Cox regression analysis to assess all\u2010cause mortality at 90\u00a0days, 1, 2, and 5\u00a0years post\u2010discharge and to examine trends in in\u2010hospital and post\u2010discharge mortality over the study period. Models were adjusted for comorbidities, heavy smoking, alcohol abuse and sociodemographic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 28,759 adults with incident acute pancreatitis, 956 (3.3%) died in hospital. The 27,803 patients discharged from the hospital following an incident episode of acute pancreatitis were matched with 139,035 individuals (mean age 58.1\u00a0years, 51.1% men). The cumulative post\u2010discharge mortality at 90\u00a0days was 5.0% for the acute pancreatitis cohort and 0.55% for controls. The mortality risk was significantly increased in acute pancreatitis patients at 90\u00a0days post\u2010discharge (adjusted hazard ratio [aHR] 7.62; 95% CI 6.86\u20138.45); the risk attenuated over time but remained elevated for up to five years (aHR 1.85; 95% CI 1.79\u20131.92). In\u2010hospital mortality decreased over the study period (aHR 0.65; 95% CI 0.53\u20130.81) from 2002\u20132005 to 2014\u20132017, while post\u2010discharge mortality risk remained stable (aHR 0.85; 95% CI 0.72\u20131.01). Gastrointestinal and cardiovascular diseases accounted for 59.4% of 90\u2010day post\u2010discharge deaths.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In\u2010hospital mortality for acute pancreatitis has improved in recent years. However, the risk of post\u2010discharge mortality remains high, especially in the first 90\u00a0days after discharge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.12766","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T06:15:02Z","timestamp":1738908902000},"page":"631-639","source":"Crossref","is-referenced-by-count":7,"title":["Increased Early Post\u2010Discharge Mortality in Patients With Acute Pancreatitis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-8144","authenticated-orcid":false,"given":"Line","family":"Davidsen","sequence":"first","affiliation":[{"name":"Centre for Pancreatic Diseases and Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg 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Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3916-3168","authenticated-orcid":false,"given":"S\u00f8ren S.","family":"Olesen","sequence":"additional","affiliation":[{"name":"Centre for Pancreatic Diseases and Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg 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