{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:57:22Z","timestamp":1754161042113,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170632"],"award-info":[{"award-number":["82170632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042024kf0040"],"award-info":[{"award-number":["2042024kf0040"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Previous results showed that combined treatment of biologics and exclusive enteral nutrition (EEN) brought moderate\u2010to\u2010severe Crohn's disease patients significant improvements in clinical and endoscopic outcomes. Despite its essential role and favorable safety profile, EEN in the treatment of adult Crohn's disease is frequently underestimated because of lower compliance and several side effects, including EEN\u2010related diarrhea (EEND).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, single\u2010center randomized clinical trial, 147 eligible patients with actively moderate\u2010to\u2010severe Crohn's disease treated with biologics and concomitant 16\u2010week EEN were included. Sixty\u2010one patients without EEND were enrolled in the ND group (without EEN\u2010related diarrhea), and other patients with EEND who received pancreatic enzyme replacement therapy (PERT) (43 patients) or not (43 patients) were recruited in PERT and NPERT groups, respectively. The clinical outcomes, biologic outcomes, and endoscopic outcomes were evaluated. Quality of life (QoL) and psychological status were also assessed at baseline and endpoints (week 16).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bowel movements (daily frequency decreased by 5.3 times) and stool consistency (reduced watery and loose stool) were greatly improved in PERT group at week 16. At week 16, patients in the ND and PERT groups achieved similar clinical responses (93% in ND group and 94.7% in PERT group, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.731) and clinical remission (86.0% in ND group and 86.8% in PERT group, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.90) while patients in the NPERT group had significantly lower proportions of these clinical outcomes (67.9% clinical response and 57.1% clinical remission). No significant difference was observed in endoscopic outcomes between each group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.904). QoL and mental status including anxiety and depression in PERT group had great improvement compared with the NPERT group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our prospective results provided invaluable evidence that PERT supplementation efficiently improved EEND in Crohn's disease patients with combined treatment of biologics and 16\u2010week EEN, which had a promising effect in active Crohn's disease induction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>ChiCTR2200058343.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.70021","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T07:22:51Z","timestamp":1744874571000},"page":"997-1011","source":"Crossref","is-referenced-by-count":1,"title":["Pancreatic Enzyme Replacement Therapy Improves Exclusive Enteral Nutrition Related Diarrhea in Crohn's Disease: A Prospective Randomized 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