{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:06:37Z","timestamp":1791648397056,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gallbladder polyps are seen in up to 7% of adults and carry a low malignancy risk. Guidelines on indication for surgery and follow\u2010up remain controversial because of regional differences in the development of malignancy. This study compares European practice guidelines for gallbladder polyps and assesses the percentage of patients in whom cholecystectomy was indicated according to the guidelines with a true adenoma postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Dutch patients with active follow\u2010up or surgery for gallbladder polyps between 2018 and 2020 in 26 participating centres were included. Data on demographics, imaging characteristics, surgery and histopathology were assessed. Indications for cholecystectomy were examined for all patients comparing 2017 and 2022 European guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A cohort of 302 patients was included. Patients in follow\u2010up underwent imaging three times (median) and were followed up during a median of 23.2\u00a0months (IQR 10.9\u201347.4). In total, 88 patients (29%) underwent cholecystectomy after a median period of 23\u00a0months and a median of two instances of imaging. In 71 of 88 patients (81%) who underwent cholecystectomy, the gallbladder polyps was a valid indication for cholecystectomy according to 2017 guidelines, compared to 68 of 88 (77%) according to 2022 guidelines. The difference only occurred due to age as a risk factor which changed from 50 to 60\u00a0years of age. Of 71 operated patients, non\u2010neoplastic polyps were found in 49 (69%), no gallbladder wall abnormality was found in 23 (32%). An adenoma was found in six patients (9%), of which three had low grade dysplasia and one had high grade dysplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite revision of guidelines in 2022, a significant number of patients still undergo follow\u2010up and cholecystectomy for non\u2010neoplastic gallbladder polyps, indicating the need for a more comprehensive risk assessment algorithm in the management of gallbladder polyps.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70057","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T07:43:21Z","timestamp":1753256601000},"page":"1133-1140","source":"Crossref","is-referenced-by-count":5,"title":["Revised Guidelines for the Treatment and Follow\u2010Up of Gallbladder Polyps Do Not Reduce Unwarranted Cholecystectomies: Results of the POLYP Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-9629","authenticated-orcid":false,"given":"Mike","family":"van Dooren","sequence":"first","affiliation":[{"name":"Department of Surgery Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise A. J.","family":"de Savornin Lohman","sequence":"additional","affiliation":[{"name":"Department of Surgery Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmila","family":"van der Bilt","sequence":"additional","affiliation":[{"name":"Department of Surgery Flevoziekenhuis  Almere the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke T.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Transplant Surgery University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamila","family":"Boerma","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Gelderse Vallei  Ede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andries E.","family":"Braat","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve M. M.","family":"de Castro","sequence":"additional","affiliation":[{"name":"Department of Surgery OLVG  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartholomeus J. G. A.","family":"Corten","sequence":"additional","affiliation":[{"name":"Department of Surgery M\u00e1xima MC  Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freek","family":"Daams","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC (location VUmc)  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris I.","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC (location AMC)  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris","family":"Ferenschild","sequence":"additional","affiliation":[{"name":"Department of Surgery Maasziekenhuis Pantein  Boxmeer the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1372-3294","authenticated-orcid":false,"given":"Ansje S.","family":"Fortuin","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital Gelderse Vallei  Ede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanette","family":"van Geloven","sequence":"additional","affiliation":[{"name":"Department of Surgery Tergooi MC  Hilversum the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"van der Hoeven","sequence":"additional","affiliation":[{"name":"Department of Radiology St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger","family":"Klicks","sequence":"additional","affiliation":[{"name":"Department of Surgery BovenIJ Hospital  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flip M.","family":"Kruyt","sequence":"additional","affiliation":[{"name":"Department of Surgery Hospital Gelderse Vallei  Ede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara S.","family":"Langenhoff","sequence":"additional","affiliation":[{"name":"Department of Surgery Elisabeth\u2010TweeSteden Hospital  Tilburg the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike S. L.","family":"Liem","sequence":"additional","affiliation":[{"name":"Department of Surgery Medisch Spectrum Twente  Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip V. M.","family":"Linsen","sequence":"additional","affiliation":[{"name":"Department of Radiology Albert Schweitzer Hospital  Dordrecht the Netherlands"},{"name":"Department of Radiology Jeroen Bosch Hospital  s\u2010Hertogenbosch the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misha","family":"Luyer","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Hospital  Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent B.","family":"Nieuwenhuijs","sequence":"additional","affiliation":[{"name":"Department of Surgery  Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"Olthof","sequence":"additional","affiliation":[{"name":"Department of Surgery  Delft the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Plaisier","sequence":"additional","affiliation":[{"name":"Department of Surgery Albert Schweitzer Hospital  Dordrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"van Rossem","sequence":"additional","affiliation":[{"name":"Department of Surgery Maasstad Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud","family":"Schrauwen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Bernhoven Hospital  Uden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Schreinemakers","sequence":"additional","affiliation":[{"name":"Department of Surgery Amphia Hospital  Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Piero","family":"Serafino","sequence":"additional","affiliation":[{"name":"Department of Radiology Jeroen Bosch Hospital  s\u2010Hertogenbosch the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst Jan Spillenaar","family":"Bilgen","sequence":"additional","affiliation":[{"name":"Department of Surgery Rijnstate Hospital  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Talsma","sequence":"additional","affiliation":[{"name":"Department of Surgery Deventer Hospital  Deventer the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merel M.","family":"Tielemans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Bravis Hospital  Roosendaal the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte J.","family":"Tutein Nolthenius","sequence":"additional","affiliation":[{"name":"Department of Radiology St. Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8566-4222","authenticated-orcid":false,"given":"Philip","family":"de Reuver","sequence":"additional","affiliation":[{"name":"Department of Surgery Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1990.12067104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2002\/787598"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i14.2171"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511896"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.3.481"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.5143"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010021\u201008384\u2010w"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.213079"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200111000\u201000011"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_9_12_1","unstructured":"E. 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