{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:19:38Z","timestamp":1790799578957,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gut\u2010directed hypnotherapy is effective for irritable bowel syndrome (IBS) and a few studies have reported long\u2010lasting therapeutic effects following intervention. No previous studies have evaluated the long\u2010term effects of nurse\u2010administered hypnotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to investigate the long\u2010term effects of nurse\u2010administered gut\u2010directed hypnotherapy for IBS and identify factors associated with symptom improvement. Furthermore, we aimed to compare treatment effects between individual and group hypnotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 2\u2010year follow\u2010up study including 289 patients with IBS who had completed a 12\u2010week hypnotherapy program (individually or in groups) was conducted. Data were collected at baseline, and at 6\u2010month\u2010, 1\u2010year\u2010 and 2\u2010year follow\u2010ups. Irritable bowel syndrome and extracolonic symptom severity (IBS\u2010SSS), gastrointestinal\u2010specific anxiety (VSI), and anxiety and depressive symptoms (HADS) were assessed. Patients reporting a reduction\u00a0\u2265\u00a050 points (IBS\u2010SSS) were classified as treatment responders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 2\u2010year follow\u2010up was completed by 207 patients. The proportion of responders at post\u2010treatment was 64.3%, 62.8% at the 6\u2010month follow\u2010up, 64.7% at the 1\u2010year follow\u2010up, and 61.8% at the 2\u2010year follow\u2010up. The severity of IBS symptoms, extracolonic and psychological symptoms were all reduced post\u2010treatment, and this effect lasted over the 2\u2010year follow\u2010up period (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Younger age, individual hypnotherapy, and severe irritable bowel syndrome symptoms at baseline predicted a better response to treatment (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.16).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nurse\u2010administered gut\u2010directed hypnotherapy is an effective treatment for IBS with long\u2010lasting symptom improvements. Younger age, severe irritable bowel syndrome symptoms, and individual treatment might be important factors associated with effectiveness (ClinicalTrials.gov study protocol IDs: NCT06167018, NCT03432078).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov study protocol IDs: NCT06167018, NCT03432078<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70060","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T02:15:41Z","timestamp":1749521741000},"page":"1307-1317","source":"Crossref","is-referenced-by-count":7,"title":["Nurse\u2010Administered Gut\u2010Directed Hypnotherapy for Irritable Bowel Syndrome: A Two\u2010Year Follow\u2010Up Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-0606","authenticated-orcid":false,"given":"Jenny","family":"L\u00f6vdahl","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Blomqvist\u2010Storm","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"EMBRACE Lab Center for Health and Medical Psychology (CHAMP) School of Behavioural Social and Legal Sciences University of \u00d6rebro  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur S.","family":"Palsson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Ringstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2117-9874","authenticated-orcid":false,"given":"Hans","family":"T\u00f6rnblom","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Simr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Division of 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