{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:19:32Z","timestamp":1761178772018,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Chromocolonoscopy significantly improves polyp\/adenoma detection rates (PDR\/ADR). However, its integration into routine clinical practice is hindered by its cumbersome mode of application. The objective was to develop an oral nutritional grade delivery system and to assess its efficacy for colonic release, mucosal staining and PDR\/ADR as a proof of concept.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Food\u2010grade shellac microcapsules releasing 87.5\u00a0mg of patent blue V (PBM) pH\u2010 and time\u2010dependently were used in 35 volunteers receiving diagnostic colonoscopy either due to a positive fecal occult blood test or surveillance in inflammatory bowel disease. Six capsules were administered p.o. during the bowel preparation (Klean\u2010Prep). Mucosal staining was assessed in total and per segment using a five\u2010point grading scale. PDR and ADR were evaluated and compared to a propensity score\u2010matched comparison cohort in a 1:3 ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the PBM cohort, 97.1% (34\/35) achieved an optimal to acceptable staining quality (SQ) score of \u2265\u00a08, with a mean total score of 13.4\u00a0\u00b1\u00a02.9. PDR was significantly higher in the PBM group at 62.8% compared to 42.9% in the comparison group (CG;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04). ADR showed no significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.06). The use of PBM resulted in a significantly increased number of detected polyps and adenomas per colonoscopy compared with CG (polyps: PMB\u00a0=\u00a01.1\u00a0\u00b1\u00a01.1 vs. CG\u00a0=\u00a00.6\u00a0\u00b1\u00a00.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02; adenomas: PBM\u00a0=\u00a00.8\u00a0\u00b1\u00a00.9 vs. CG\u00a0=\u00a00.3\u00a0\u00b1\u00a00.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The novel PBM demonstrated uniform mucosal staining when utilized in chromocolonoscopy. Delayed\u2010release patent blue V appears to be a safe and effective alternative to dye\u2010spray techniques and existing oral chromoendoscopy modalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70067","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T04:48:48Z","timestamp":1751690928000},"page":"1116-1126","source":"Crossref","is-referenced-by-count":0,"title":["Oral Microcapsule Chromocolonoscopy With Patent Blue V Improves Adenoma Detection Safely and Effectively"],"prefix":"10.1002","volume":"13","author":[{"given":"Berenice","family":"Schulte","sequence":"first","affiliation":[{"name":"Interdisciplinary Endoscopy Department of Internal Medicine I University Hospital Schleswig\u2010Holstein Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg H.","family":"Waetzig","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology Christian\u2010Albrechts\u2010University Kiel and University Hospital Schleswig\u2010Holstein, Campus Kiel  Kiel Germany"},{"name":"CONARIS Research Institute AG  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Bethge","sequence":"additional","affiliation":[{"name":"Interdisciplinary Endoscopy Department of Internal Medicine I University Hospital Schleswig\u2010Holstein Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Aden","sequence":"additional","affiliation":[{"name":"Interdisciplinary Endoscopy Department of Internal Medicine I University Hospital Schleswig\u2010Holstein Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0219-9054","authenticated-orcid":false,"given":"Claudio C.","family":"Conrad","sequence":"additional","affiliation":[{"name":"Interdisciplinary Endoscopy Department of Internal Medicine I University Hospital Schleswig\u2010Holstein Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva\u2010Maria","family":"Theismann","sequence":"additional","affiliation":[{"name":"Division of Food Technology Christian\u2010Albrechts\u2010University Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia K.","family":"Keppler","sequence":"additional","affiliation":[{"name":"Division of Food Technology Christian\u2010Albrechts\u2010University Kiel  Kiel Germany"},{"name":"Department of Agrotechnology and Food Sciences Laboratory of Food Process Engineering Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Ruhmlieb","sequence":"additional","affiliation":[{"name":"Division of Food Technology Christian\u2010Albrechts\u2010University Kiel  Kiel 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