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However, the potential relationship and mechanisms between the ileocecum and remission induction of CD are still elusive. In this study, we conducted 16S rRNA sequencing and liquid chromatography\u2013tandem mass spectrometry (LC\u2010MS\/MS) on 68 terminal ileal mucosa and mesentery samples from 34 patients with CD. The results showed an improvement in the microbial health of the ileal mucosa and mesentery in patients with CD after ileocecal resection. In addition, specific spatial alterations in microbiota and metabolites were observed before and after surgery. Furthermore, differentially expressed metabolites in the ileal mucosa and mesentery were subjected to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. The findings of this study support the therapeutic value of ileocecal resection in CD from a multi\u2010omics perspective and may guide the clinical translation of microbiome\u2010based strategies for precise treatment of CD.<\/jats:p>","DOI":"10.1002\/ueg2.70069","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T10:11:43Z","timestamp":1750327903000},"page":"1239-1252","source":"Crossref","is-referenced-by-count":1,"title":["Multi\u2010Omics Analysis of Ileal Mucosa and Mesentery Before and After Ileocecal Resection in Crohn's Disease"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-0341","authenticated-orcid":false,"given":"Kai","family":"Xia","sequence":"first","affiliation":[{"name":"Department of General Surgery Yangpu Hospital Tongji University School of Medicine  Shanghai China"},{"name":"Institute of Gastrointestinal Surgery and Translational Medicine Tongji University School of Medicine  Shanghai 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