{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:35:38Z","timestamp":1791898538309,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020209","name":"Shaanxi Provincial Health Commission","doi-asserted-by":"publisher","award":["2024TD\u201006"],"award-info":[{"award-number":["2024TD\u201006"]}],"id":[{"id":"10.13039\/501100020209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Vonoprazan and amoxicillin dual therapy has demonstrated favorable efficacy in the initial treatment of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) infection. This study aimed to evaluate the efficacy and safety of vonoprazan and high\u2010dose amoxicillin (VHA) dual therapy for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      rescue treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was an open label, multicenter, non\u2010inferiority, and randomized controlled clinical trial conducted at four institutions in both central and northwestern China. A total of 688\n                      <jats:italic>H. pylori\u2010<\/jats:italic>\n                      infected patients who had failed previous treatments were randomly assigned (1:1) to receive either VHA dual therapy or the tetracycline\u2010 and furazolidone\u2010based bismuth\u2010containing quadruple therapy (TFEB) for 14\u00a0days. Eradication rates, adverse event (AE) rates, and the patient compliance were compared between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The eradication rates in the VHA and TFEB groups were 73.8% and 76.2% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.481), respectively, by intention\u2010to\u2010treat (ITT) analysis; 81.9% and 85.6% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.215), respectively, by modified ITT (MITT) analysis; and 82.1% and 85.6% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.248), respectively, by per\u2010protocol (PP) analysis. VHA therapy remained non\u2010inferior to TFEB in ITT, MITT, and PP analyses. The overall AE incidence in the VHA group was significantly lower compared with that in the TFEB group (13.4% vs.. 28.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Patients' compliance was similar between the two groups. A history of multiple prior eradication failures was an independent risk factor (2 failures: OR\u00a0=\u00a00.566,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.032; \u2265\u00a03 failures: OR\u00a0=\u00a00.335,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) reducing the efficacy of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      rescue therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The 14\u2010day VHA dual therapy was non\u2010inferior to bismuth\u2010containing quadruple therapy, with a lower incidence of adverse events and good compliance, and may represent an effective alternative for\n                      <jats:italic>H.pylori<\/jats:italic>\n                      rescue treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This trial was registered at ClinicalTrials.gov (No. NCT06168084)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70070","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T13:09:44Z","timestamp":1750511384000},"page":"1541-1549","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy and Safety of Vonoprazan and High\u2010Dose Amoxicillin Dual Therapy for Rescue Treatment of\n                    <i>Helicobacter pylori<\/i>\n                    Infection: A Multicenter Randomized Controlled Trial"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3118-1121","authenticated-orcid":false,"given":"Ju","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Holistic Integrative 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