{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:28:59Z","timestamp":1761157739455,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early advanced inflammatory bowel disease (IBD) therapy is emphasised to prevent disease progression and restore quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the potential advantages of early versus late anti\u2010tumour necrosis factor (TNF) therapy in patients with IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included patients with newly diagnosed IBD (2004\u20132018) who received anti\u2010TNF therapy and had at least 1\u00a0year of follow\u2010up. Patients were categorised as early or late users based on a 2\u2010year post\u2010diagnosis cut\u2010off for first anti\u2010TNF exposure. Outcomes included IBD\u2010related surgeries, hospitalizations, emergency department (ED) visits, and drug persistence. Subgroup analysis examined concurrent immunomodulator use, and sensitivity analyses were employed 6\u00a0months or 1\u00a0year post\u2010diagnosis cut\u2010offs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 8105 patients with ulcerative colitis (UC) and 8465 with Crohn's disease (CD), distinct outcomes emerged. Early anti\u2010TNF users with UC had significantly higher hospitalization (hazard ratio [HR] 1.34, 95% confidence interval [CI] 0.91\u20131.96) and ED visit rates (HR 1.30, 95% CI 1.16\u20131.46) compared with late users. In CD, early users showed a non\u2010significant trend toward fewer event rates. Drug persistence was longer among late users for both UC and CD. In UC, combining immunomodulators with early anti\u2010TNF increased hospitalization and ED visits but not in CD. Sensitivity analyses confirmed the primary findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While early anti\u2010TNF use was associated with differential outcomes in CD, the relationship between treatment timing and clinical course diverged in UC, challenging the assumption that early intervention is universally advantageous across IBD subtypes. These findings underscore the need for further research to identify patient subgroups that might benefit most from early intervention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ueg2.70071","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T12:34:24Z","timestamp":1750768464000},"page":"1502-1512","source":"Crossref","is-referenced-by-count":1,"title":["Differential Outcomes of Early Versus Late Anti\u2010TNF Therapy in Ulcerative Colitis and Crohn's Disease: A Nationwide Propensity Score\u2010Matched Cohort Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0470-1026","authenticated-orcid":false,"given":"Shin Ju","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Center for Crohn's and Colitis Kyung Hee University Hospital Kyung Hee University College of Medicine  Seoul 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