{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:51:05Z","timestamp":1788202265765,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      European guidelines recommend that susceptibility tests be routinely performed, even before prescribing first\u2010line treatment of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection. However, empirical treatments are the rule in France, and susceptibility\u2010guided treatments are the exception.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to report our experience of systematic antibiotic susceptibility testing before first\u2010line treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective registration of all esofagogastroduodenoscopies performed in a community hospital from December 2023 to December 2024. Antral and fundic biopsies were performed, at the discretion of the endoscopist, for histological examination, polymerase chain reaction (PCR) and culture without any freezing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 3566 adults underwent esofagogastroduodenoscopy, 1785 (50.1%) were tested and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection was diagnosed in 308 (17.3%) [95% confidence interval (CI): 15.5%\u201319.0%] individuals. The sensitivity of PCR for the diagnosis of\n                      <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      infection was 99.7%, significantly higher than those of histology (94.1%) and culture (95.2%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Clarithromycin resistance was observed in 22.6% [95% CI: 17.9%\u201327.3%] and levofloxacin resistance in 18.6% [95% CI: 14.1%\u201323.2%] of cases. Among 285 patients treated, susceptibility\u2010guided triple therapy was prescribed in 84.9% of cases (73.3% amoxicillin\u2010clarithromycin, 11.6% amoxicillin\u2010levofloxacin) and quadruple bismuth therapy in 14.4% of cases. The eradication rates were 98.1% [95% CI: 96.0%\u2013100%] for triple therapy amoxicillin\u2010clarithromycin and 100% [95% CI: 100%\u2013100%] for amoxicillin\u2010levofloxacin, significantly higher than 81.3% [95% CI: 67.7%\u201394.8%] for quadruple bismuth therapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03, respectively). Overall, of 218 (70.8%) patients evaluated by the C13 urea breath test,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      was eradicated in 209 (95.9%) [95% CI: 93.2%\u201398.5%] patients. The PCR\u2010based diagnostic and therapeutic strategy was more cost\u2010effective than the immunohistochemistry\u2010based strategy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A PCR\u2010based susceptibility\u2010guided strategy is easy to implement in routine clinical practice. In more than 7 in 10 patients, PCR enabled the offer of a susceptibility\u2010guided triple therapy that was more effective and less costly than empirical quadruple bismuth therapy. Culture enabled one additional patient in 10 to be offered a susceptibility\u2010guided triple therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70090","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T13:14:43Z","timestamp":1755782083000},"page":"1289-1294","source":"Crossref","is-referenced-by-count":2,"title":["Systematic Evaluation of\n                    <i>Helicobacter pylori<\/i>\n                    Susceptibility to Antibiotics Before First\u2010Line Treatment: A Cohort Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-8826","authenticated-orcid":false,"given":"Bernard","family":"Denis","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Pasteur Hospital  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurianne","family":"Plastaras","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Pasteur Hospital  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella","family":"Amaritei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Pasteur Hospital  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Bolliet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Pasteur Hospital  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Clavel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Pasteur Hospital  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Darrius","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Pasteur Hospital  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Montet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Pasteur Hospital  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Vuola","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Pasteur Hospital  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"de Briel","sequence":"additional","affiliation":[{"name":"Department of Biology Pasteur Hospital  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01867\u20101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(18)30605\u20104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(19)30488\u20107"},{"key":"e_1_2_9_5_1","unstructured":"Haute Autorit\u00e9 de Sant\u00e9 Traitement de l\u2019infection parHelicobacter pylorichez l\u2019adulte(2017) https:\/\/www.has\u2010sante.fr\/upload\/docs\/application\/pdf\/201706\/dir83\/helicobacter_fiche_pertinence_traitement.pdf."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102022\u2010327745"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13076"},{"key":"e_1_2_9_8_1","unstructured":"Haute Autorit\u00e9 de Sant\u00e9 Pertinence des actes et prescriptions m\u00e9dicamenteuses chez un patient adulte infect\u00e9 parHelicobacter pylori(2017) https:\/\/www.has\u2010sante.fr\/upload\/docs\/application\/pdf\/2017\u201006\/dir83\/helicobacter_rapport_elaboration.pdf."},{"issue":"15","key":"e_1_2_9_9_1","first-page":"275","article-title":"\u00c9pid\u00e9miologie de l\u2019infection \u00e0 Helicobacter pylori en France en 2020: Donn\u00e9es de surveillance du CNR Campylobacters et H\u00e9licobacters","author":"B\u00e9n\u00e9jat L.","year":"2021","journal-title":"Bulletin 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