{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:31:59Z","timestamp":1789835519409,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>While significant advances have been made in identifying biomarkers for predicting inflammatory bowel disease (IBD) onset, little is known about the willingness of at\u2010risk individuals to undergo predictive testing and preventive interventions. This study aimed to assess acceptance of predictive tests and preventive interventions among individuals at risk of inflammatory bowel disease and identify factors influencing their decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An anonymized electronic survey was distributed to parents of children at risk of inflammatory bowel disease and first\u2010degree relatives (FDRs) of IBD patients via clinicians and patient associations. The survey assessed acceptance of predictive tests, preventive interventions, and influencing variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1327 participants (74% women, mean age 42\u00a0\u00b1\u00a018\u00a0years) from 66 countries responded to the survey. Of these, 88% were parents of children at risk, and 12% were FDRs. Eighty\u2010five percent were willing to embark in predictive testing, preferring blood analysis (91%), stool tests (89%), saliva tests (78%) or intestinal ultrasound (67%). Lower perceived IBD impact and higher disease knowledge reduced the odds of test acceptance. Preventive interventions were accepted by 98%, with dietary changes (85%), physical exercise (81%), and probiotics (71%) being the preferred. Acceptance of oral (38%) or intravenous\/subcutaneous immunosuppressive treatments (32%) depended on their efficacy, difficulty, and risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most respondents preferred minimally invasive predictive tests and non\u2010pharmacological preventive measures, although more than one\u2010third would be willing to undergo immunosuppressive medications to prevent disease onset. Disease knowledge and quality\u2010of\u2010life perceptions influenced preferences. This data provides important information for the development of IBD prediction and prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70091","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:56:34Z","timestamp":1755604594000},"page":"1226-1238","source":"Crossref","is-referenced-by-count":5,"title":["Patient and First\u2010Degree Relatives Perceptions About Prediction and Prevention of Inflammatory Bowel Disease\u2014A Multinational Survey"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1072-9053","authenticated-orcid":false,"given":"Ana Catarina","family":"Bravo","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Hospital Beatriz \u00c2ngelo  Loures Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Godt","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Julsgaard","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT) Department of Clinical Medicine Aalborg University  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-4578","authenticated-orcid":false,"given":"Iago","family":"Rodriguez\u2010Lago","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Universitario de Galdakao  Galdakao Spain"},{"name":"Biobizkaia Health Research Institute  Galdakao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Exposito","sequence":"additional","affiliation":[{"name":"ACCU \u2010 Confederaci\u00f3n de asociaciones de enfermos de Crohn y Colitis Ulcerosa de Espa\u00f1a  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ginard","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Universitario Son Espases  Palma Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Juillerat","sequence":"additional","affiliation":[{"name":"Intesto\u00a0\u2010 Gastroenterologische Praxis &amp; Crohn\u2010Colitis\u2010Zentrum  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi Gram","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Medicine Regional Hospital G\u00f8dstrup  Gj\u00f8dstrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5623-2968","authenticated-orcid":false,"given":"Gionata","family":"Fiorino","sequence":"additional","affiliation":[{"name":"IBD Unit Gastroenterology and Digestive Endoscopy San Camillo\u2010Forlanini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Buisson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne Inserm CHU Clermont\u2010Ferrand 3iHP Service d'H\u00e9pato\u2010Gastro Ent\u00e9rologie  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickolas","family":"Stemmer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology Staedtisches Klinikum Lueneburg  L\u00fcneburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Solare Educa Hub  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Ribas","sequence":"additional","affiliation":[{"name":"Department of Life Science Bahia State University UNEB  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viv\u00edana Parra","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Hospital Internacional de Colombia  Bucaramanga Colombia"},{"name":"Cellular and Molecular Immunilogy Group (INMUBO) Universidad El Bosque  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey A.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Center for Digestive Health Section of Gastroenterology and Hepatology Dartmouth Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Croitoiru","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Zane Cohen Centre for Digestive Diseases Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology &amp; 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