{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:04:18Z","timestamp":1780506258305,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010423","name":"Ministry of Culture and Sport","doi-asserted-by":"publisher","award":["4361"],"award-info":[{"award-number":["4361"]}],"id":[{"id":"10.13039\/501100010423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["785\/22"],"award-info":[{"award-number":["785\/22"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["758313"],"award-info":[{"award-number":["758313"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Elderly\u2010onset inflammatory bowel disease (IBD) patients (age \u2265\u00a060 at diagnosis) have unique characteristics that require special consideration. Using a real\u2010life registry\u2010based cohort, we compared disease phenotypes and treatment exposures between adult\u2010onset (18\u00a0\u2264\u00a0age &lt;\u00a060\u00a0years) and elderly\u2010onset IBD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Demographics, disease characteristics, and treatment were compared between adult\u2010 and elderly\u2010onset IBD patients diagnosed during 2000\u20132022 with \u2265\u00a012\u00a0months follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 3307 adult IBD patients, 290 (9%) were elderly\u2010onset. This group exhibited a higher prevalence of colon\u2010only involvement, with higher rates of ulcerative colitis (UC, 38.3% vs. 31.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) and more colonic L2 Crohn's Disease (CD, 21% vs. 12%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) then adult\u2010onset group. Elderly\u2010onset CD also showed less ileocolonic L3 disease (14% vs. 29%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), less penetrating B3 phenotype (7.4% vs. 19%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and less perianal involvement (10% vs. 20%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Elderly\u2010onset CD and UC patients received more 5\u2010ASA (36% vs. 17%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 in CD and 75% vs. 63%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02 in UC). In contrast, these patients were exposed to considerably less biologics and\/or JAK inhibitors (37% vs. 56% for CD and 20% vs. 35% for UC,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), with higher 15\u2010year biologic\u2010free survival among elderly\u2010onset IBD. First\u2010line biological choices also substantially differed, with adult\u2010onset receiving more anti\u2010TNFs and elderly\u2010onset receiving more Vedolizumab. We did not observe higher rates of IBD\u2010related surgeries and steroid use between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elderly\u2010onset IBD shows higher prevalences of colon\u2010only IBD (UC and L2 CD). Treatment strategies in elderly\u2010onset IBD favor 5\u2010ASA and show reduced biological use, with preferences for Vedolizumab over anti\u2010TNFs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70092","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T16:39:39Z","timestamp":1754584779000},"page":"1754-1764","source":"Crossref","is-referenced-by-count":3,"title":["Elderly\u2010Onset Inflammatory Bowel Disease Has Distinct Disease Characteristics and Treatment Patterns"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1553-5847","authenticated-orcid":false,"given":"Maya","family":"Granot","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Edmond and Lily Safra Children's Hospital Sheba Medical Center  Ramat Gan Israel"},{"name":"School of Medicine Faculty of Medical and Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv 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