{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:55:16Z","timestamp":1786978516311,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mucosal healing (MH) is a key treatment goal in Crohn's disease (CD). However, evidence on pan\u2010enteric MH (PE\u2010MH) in CD patients treated with vedolizumab remains limited. We aimed to assess vedolizumab efficacy in achieving PE\u2010MH using PillCam Crohn's capsule.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, open\u2010label observational study included CD patients with intestinal inflammation (SB\u2010Lewis score [LS]\u00a0\u2265\u00a0220 and\/or colonic\u2010Eliakim score [ES]\u00a0&gt;\u00a00) who initiated vedolizumab and were followed with C\u2010reactive protein (CRP), fecal calprotectin (FCP), and PillCam Crohn's capsule at baseline and after 14 and 52\u00a0weeks. In cases of exclusive SB involvement, colonic preparation and assessment were omitted. LS and ES were calculated when applicable. The primary outcome was PE\u2010MH, defined as LS\u00a0&lt;\u00a0135 for SB\u2010VCE assessment, and ES\u00a0=\u00a00 for PE\u2010VCE assessment. Secondary outcomes included SB\u2010MH (LS\u00a0&lt;\u00a0135), colonic\u2010MH (ES\u00a0=\u00a00) and biochemical remission (FCP\u00a0&lt;\u00a0150\u00a0\u03bcg\/g). An exploratory outcome for SB\u2010MH was defined as a LS\u00a0&lt;\u00a0350, which has previously been shown to predict future flares in CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 60 screened patients, 44 were enrolled (median age: 29.0 [22.0\u201345.5] years; 43.2% male; Ileum [L1]\u201054.5%, Colon [L2]\u201041.0%, Ileo\u2010colon [L3]\u20104.5%). At week 52, 7\/44 (15.9%) patients reached PE\u2010MH compared to baseline (risk difference [RD] 15.9%, 95% confidence interval [CI] 5.1%\u201326.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.016). 8\/44 (18.2%) and 9\/44 (20.5%) patients achieved SB\u2010MH at week 52 and 14, respectively, compared to 2\/44 (4.5%) at baseline. Using the less stringent SB\u2010MH criterion (LS\u00a0&lt;\u00a0350), rates improved significantly at week 52 versus baseline (45.5% vs. 25.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.049). All study indices decreased during follow\u2010up (baseline, week 14, week 52): CRP (11.8, 5.8, 5.0:\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.152), FCP (758, 418, 158:\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004), LS (900, 225, 225,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and ES (18.0, 4.0, 4.0:\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). 14\/44 (31.8%) patients reached biochemical remission (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.049) at week 52 compared to 5\/44 (11.4%) at baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vedolizumab treatment led to significant biochemical and endoscopic improvement, including SB\u2010MH and PE\u2010MH, through 52\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70103","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T16:39:07Z","timestamp":1757263147000},"page":"1974-1983","source":"Crossref","is-referenced-by-count":3,"title":["Vedolizumab Achieves Pan\u2010Enteric Mucosal Healing in Crohn's Disease: A Prospective Observational Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8601-6550","authenticated-orcid":false,"given":"Offir","family":"Ukashi","sequence":"first","affiliation":[{"name":"Sheba Medical Center Tel Hashomer Faculty of Medical and Health Sciences Gastroenterology Institute Tel\u2010Aviv University  Tel Aviv 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