{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:14:27Z","timestamp":1783455267781,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/0924"],"award-info":[{"award-number":["PI20\/0924"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI24\/0729"],"award-info":[{"award-number":["PI24\/0729"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The global incidence and mortality of early\u2010age onset colorectal cancer (EOCRC, or CRC diagnosed under 50\u00a0years) has increased in recent decades. High\u2010risk surveillance and personalised oncological treatment may improve patients' outcomes. This study aims to characterise real\u2010world somatic and germline molecular profiles in European EOCRC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Consecutive patients across the UK, Spain, Germany and Italy from the GEOCODE and SECOC consortia were identified using electronic patient records. Clinicopathological, somatic and germline testing data were collected on EOCRC patients. Tests included mismatch repair (MMR), somatic next generation sequencing (NGS) and germline multi\u2010gene panels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight hundred ninety\u2010three EOCRC patients were identified from 23 European centres (45.7% female, median age 42, range 14\u201349), predominantly in the distal colorectum: 205\/893 (22.9%) patients with right\u2010sided tumours, 302\/893 (33.8%) left\u2010sided tumours, 288\/893 (32.2%) rectal tumours and 97\/893 (10.8%) unknown. On somatic analysis, 735\/893 (82.3%) of patients had pMMR tumours and 148\/893 (16.5%) dMMR. Although 534\/893 (59.7%) did not receive NGS somatic testing, somatic variants were detected in 233\/359 (64.9%) of those tested. Germline variants were detected in 133\/210 (63.3%) patients tested. Lynch syndrome was diagnosed in 93\/210 (44.2%), of whom 17\/93 (18.2%) presented with pMMR tumours. Systematic recording of family history in these real\u2010world data was variable. In all patients with family history recorded, 153\/484 (31.4%) patients reported a relative with CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results support universal and paired somatic and germline multi\u2010gene panels for all EOCRC patients, regardless of MMR status or family history. Systematic molecular testing approaches are necessary to address disparities in people with EOCRC. Larger unselected cohort studies would support validation of testing prediction models and estimates of clinically relevant variant actionability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70112","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:45:14Z","timestamp":1758980714000},"page":"2012-2022","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010World Molecular Testing in European Early\u2010Onset Colorectal Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3244-8902","authenticated-orcid":false,"given":"Penelope V.","family":"Edwards","sequence":"first","affiliation":[{"name":"The Centre for Familial Intestinal Cancer St Mark's Hospital London Northwest Healthcare Trust  London UK"},{"name":"Cancer Genetics Royal Marsden NHS Trust  London UK"},{"name":"Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kussai Giuma","family":"Ali Eloussta","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Latchford","sequence":"additional","affiliation":[{"name":"The Centre for Familial Intestinal Cancer St Mark's Hospital London Northwest Healthcare Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Faiz","sequence":"additional","affiliation":[{"name":"The Centre for Familial Intestinal Cancer St Mark's Hospital London Northwest Healthcare Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-229X","authenticated-orcid":false,"given":"Huw","family":"Thomas","sequence":"additional","affiliation":[{"name":"The Centre for Familial Intestinal Cancer St Mark's Hospital London Northwest Healthcare Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-1316","authenticated-orcid":false,"given":"Filomena","family":"Liccardo","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Pawa","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9957-8299","authenticated-orcid":false,"given":"Robert","family":"H\u00fcneburg","sequence":"additional","affiliation":[{"name":"National Center for Hereditary Tumour Syndromes University Hospital Bonn  Bonn Germany"},{"name":"Department of Internal Medicine I University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Nattermann","sequence":"additional","affiliation":[{"name":"National Center for Hereditary Tumour Syndromes University Hospital Bonn  Bonn Germany"},{"name":"Department of Internal Medicine I University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"George","sequence":"additional","affiliation":[{"name":"Cancer Genetics Royal Marsden NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-0539","authenticated-orcid":false,"given":"Francesc","family":"Balaguer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednic de Barcelona Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Department of Surgery Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"IRCCS Humanitas Research Hospital Division of Colon &amp; Rectal Surgery  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Foppa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"IRCCS Humanitas Research Hospital Division of Colon &amp; Rectal Surgery  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel F. 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