{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:40:21Z","timestamp":1793882421966,"version":"4.7.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, mainly due to its aggressive nature, early metastasis, diagnosis at late stages, and limited response to systemic anticancer therapy. Perineural invasion (PNI), defined as the infiltration of neoplastic cells along nerve fibers and within nerve sheaths, is emerging as a critical determinant of PDAC aggressiveness. This position paper by the\n                    <jats:italic>TRANSPAN PNI Group on Perineural Invasion<\/jats:italic>\n                    synthesizes current evidence on the molecular features and clinical implications of PNI in PDAC, compares its prognostic significance in other malignancies, and describes novel biomarker strategies including potential therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1002\/ueg2.70118","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T14:14:58Z","timestamp":1758550498000},"page":"1678-1689","source":"Crossref","is-referenced-by-count":8,"title":["Perineural Invasion in Pancreatic Ductal Adenocarcinoma: Recapitulating Its Importance and Defining Future Directions"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-9643","authenticated-orcid":false,"given":"Martin","family":"Lovecek","sequence":"first","affiliation":[{"name":"Department of Surgery, University Hospital Olomouc Fakultni nemocnice Olomouc  Olomouc Czech\u00a0Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5811-4234","authenticated-orcid":false,"given":"Esra","family":"Dirimtekin","sequence":"additional","affiliation":[{"name":"Cancer Mechanisms and Biomarkers Research Group University of Westminster  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-6896","authenticated-orcid":false,"given":"Ingrid","family":"Garajov\u00e1","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit Azienda Ospedaliero\u2010Universitaria di Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2273-9773","authenticated-orcid":false,"given":"Giulia","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Division of Pancreatic Surgery, Pancreas Translational &amp; Clinical Research Center Universita Vita Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7370-1508","authenticated-orcid":false,"given":"Stefano","family":"Crippa","sequence":"additional","affiliation":[{"name":"Division of Pancreatic Surgery, Pancreas Translational &amp; Clinical Research Center Universita Vita Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7565-7504","authenticated-orcid":false,"given":"Elisa","family":"Giovannetti","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Lab of Medical Oncology, Cancer Center Amsterdam Amsterdam UMC Locatie VUmc Afdeling Medische Oncologie  Amsterdam the Netherlands"},{"name":"Cancer Pharmacology Lab, AIRC Start\u2010Up Unit Fondazione Pisana per la Scienza  San Giuliano Terme Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1925-2892","authenticated-orcid":false,"given":"Dana","family":"Sochorova","sequence":"additional","affiliation":[{"name":"Department of Surgery Tomas Bata Hospital Zlin  Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Mota","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Surgery, TUM University Hospital Klinikum rechts der Isar der Technischen Universitat Munchen Krankenhausapotheke  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihsan Ekin","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Surgery, TUM University Hospital Klinikum rechts der Isar der Technischen Universitat Munchen Krankenhausapotheke  Munich Germany"},{"name":"Else Kr\u00f6ner Clinician Scientist Professor for Translational Pancreatic Surgery  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-8831","authenticated-orcid":false,"given":"Pinar","family":"Uysal\u2010Onganer","sequence":"additional","affiliation":[{"name":"Cancer Mechanisms and Biomarkers Research Group University of Westminster  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TRANSPAN PNI Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","first-page":"1","article-title":"Perineural Invasion of Cancer: A Complex Crosstalk Between Cells and Molecules in the Perineural Niche","volume":"9","author":"Chen S. 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