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Based on new information and appraisal of current evidence, the following recommendations can be suggested: During skin preparation, we suggest using alcohol\u2010based chlorhexidine for clean, clean\u2010contaminated, and contaminated GI and HBP surgical field preparation in the absence of a mucous membrane (e.g., stoma, genitalia, anus). Preoperatively, we suggest that corticosteroids and anti\u2010TNF medication be discontinued. No recommendations could be made on the following comparisons, given the paucity of high\u2010quality evidence and panel discussion not favouring one intervention over the other based on clinical experience: 2%\u20133% chlorhexidine gluconate versus aqueous povidone\u2010iodine for surgical field preparation. 4%\u20135% chlorhexidine gluconate versus aqueous povidone\u2010iodine for surgical field preparation. Aqueous chlorhexidine gluconate versus aqueous povidone\u2010iodine for surgical field preparation Pre\u2010operative dexamethasone in single\u2010dose versus no pre\u2010operative dexamethasone for patients undergoing GI surgery. Discontinuing Vedolizumab preoperatively versus continuing Vedolizumab preoperatively for patients undergoing GI surgery. Discontinuing Ustekinumab preoperatively versus continuing Ustekinumab preoperatively for patients undergoing GI\u00a0surgery.<\/jats:p>","DOI":"10.1002\/ueg2.70128","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:05:57Z","timestamp":1761397557000},"page":"1887-1904","source":"Crossref","is-referenced-by-count":6,"title":["European Guideline on Pre\u2010Operative Prevention of Surgical Site Infections Following Digestive Surgery: A Joint Update of the WHO SSI Guideline for Gastrointestinal Surgery by UEG, ESCP, EAES, and SIS\u2010E"],"prefix":"10.1002","volume":"13","author":[{"name":"UEG\/ESCP\/EAES\/SSI\u2010E SSI Prevention Working Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Global Guidelines Prevention Surgical Site Infection","author":"World Health Organization","year":"2016"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4305"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2019.07.010"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2017.03.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20104801.2004.00067.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2006.7.s\u201019"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473\u20103099(18)30101\u20104"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304\u2010022\u201001243\u20103"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.174"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010023\u201010477\u20100"},{"key":"e_1_2_12_12_1","volume-title":"Handbook Grading Quality Evidence Strength Recommendations Using GRADE Approach","author":"GRADE Working Group","year":"2013"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.01.012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.09.002"},{"key":"e_1_2_12_15_1","unstructured":"CDC National Healthcare Safety Network: Surgical Site Infection Event[Internet] (CDC January 2025) www.cdc.gov."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_2_12_17_1","volume-title":"Cochrane Handbook Systematic Reviews Interventions Version 6","author":"Higgins J.","year":"2024"},{"key":"e_1_2_12_18_1","unstructured":"GRADEPro [Internet] GRADEPro GDT (GRADEPro January 26 2025) https:\/\/www.gradepro.org\/."},{"issue":"11","key":"e_1_2_12_19_1","first-page":"1197","article-title":"Is Chlorhexidine\u2010Gluconate Superior Than Povidone\u2010Iodine in Preventing Surgical Site Infections? 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