{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:00:36Z","timestamp":1784808036906,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006012","name":"Christian Doppler Forschungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020617","name":"\u00d6sterreichische Gesellschaft f\u00fcr Gastroenterologie und Hepatologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010132","name":"\u00d6sterreichische Nationalstiftung f\u00fcr Forschung, Technologie und Entwicklung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Complications related to portal hypertension (PH) in patients with alcohol\u2010related liver disease (ALD) can be controlled by transjugular intrahepatic portosystemic shunt (TIPS) placement; however, the impact of ongoing alcohol use (AU) after TIPS remains scarcely investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      ALD patients undergoing TIPS implantation between 2000 and 2022 were included. Laboratory\/demographic parameters and clinical events\/outcomes were compared per post\u2010TIPS AU status and to a group of\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a055 decompensated ALD patients with ongoing AU who did not receive TIPS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 248 TIPS patients (78.2% male; median age: 55.5\u00a0years; ascites: 69.8%; median MELD: 12), including 90 (36.3%) with ongoing AU after TIPS were included. AU post\u2010TIPS was independently associated with ACLF (asHR 2.27; 95% CI 1.40\u20133.66;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and liver\u2010related death (asHR 1.68; 95% CI 1.05\u20132.67;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030) among patients undergoing TIPS in adjusted multivariable competing risks analysis. When comparing matched decompensated AU patients treated versus non\u2010treated by TIPS, multivariable competing risks regression revealed MELD (asHR 1.07; 95% CI 1.01\u20131.13;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.033) but not TIPS use (asHR 0.70; 95% CI 0.45\u20131.10;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.120) as independent risk factors for ACLF, despite TIPS patients having higher levels of systemic inflammation (CRP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post\u2010TIPS AU was frequent and an independent risk factor for ACLF and liver\u2010related death, underlining the importance of interdisciplinary measures supporting alcohol abstinence. TIPS should still not be withheld from ALD patients developing PH complications, since it does not predispose them to ACLF and may prevent liver\u2010related death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70131","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:05:42Z","timestamp":1764079542000},"source":"Crossref","is-referenced-by-count":3,"title":["Alcohol Use After TIPS Implantation Significantly Increases the Risk of ACLF and Liver\u2010Related Death"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7762-7483","authenticated-orcid":false,"given":"Caroline","family":"Schwarz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine IV Klinik Ottakring  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kornfehl","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab Division of Gastroenterology and Hepatology Department of Medicine III Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Abid","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine III Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"M\u00fcllner\u2010Bucsics","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab Division of Gastroenterology and Hepatology Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna  Vienna 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Hepatology Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab Division of Gastroenterology and Hepatology Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna  Vienna Austria"},{"name":"Christian Doppler Lab for Portal Hypertension and Liver Fibrosis Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4615-915X","authenticated-orcid":false,"given":"Nina","family":"Dominik","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab Division of Gastroenterology and Hepatology Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University 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