{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:48:30Z","timestamp":1790707710619,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Filgotinib is a preferential Janus kinase 1 (JAK\u20101) inhibitor registered for the treatment of ulcerative colitis (UC). Real\u2010world effectiveness of filgotinib, especially for difficult\u2010to\u2010treat (DTT, failure of \u2265 2 prior advanced therapies) patients, has been scarcely reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess the effectiveness and safety of filgotinib for UC patients in routine care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Dutch ICC registry enrolled UC patients initiating filgotinib and prospectively evaluated outcomes up to 52\u00a0weeks. The primary outcome was corticosteroid\u2010free clinical remission (CSFR, Simple Clinical Colitis Activity Index [SCCAI]\u00a0\u2264\u00a02 without steroid use) at week 52. Secondary outcomes included clinical remission (SCCAI \u2264 2), biochemical remission (C\u2010reactive protein serum concentration &lt; 5\u00a0mg\/L and\/or faecal calprotectin level &lt; 250 \u03bcg\/g), treatment persistence and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 96 UC patients were included. At 52\u00a0weeks, 39.5% (34\/76) of patients with disease activity at baseline were in CSFR. Out of the patients that met the criteria for DTT disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a068; 71%), 36.4% achieved CSFR. Treatment persistence at 52\u00a0weeks was 71.4% (CI 56.5\u201390.3) and 53.4% (CI 42.6\u201367.0) for non\u2010DTT and DTT patients, respectively. The main reasons for discontinuation of filgotinib were primary non\u2010response (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a021, 54%) or secondary loss of response (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08, 23%). No severe infections were documented. Most reported adverse events included headache (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05), nausea (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03) and hypercholesterolemia (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Filgotinib is an effective and well\u2010tolerated treatment option for UC, including DTT disease. No new safety signals were found.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70141","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T11:49:29Z","timestamp":1764935369000},"source":"Crossref","is-referenced-by-count":2,"title":["Filgotinib Is an Effective and Safe Treatment Option for Difficult\u2010To\u2010Treat Ulcerative Colitis: Real\u2010World Evidence of the Dutch Initiative on Crohn and Colitis (ICC) Registry"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-3765","authenticated-orcid":false,"given":"M. R.","family":"Naber","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Centre Utrecht  Utrecht the Netherlands"},{"name":"Department of Gastroenterology and Hepatology Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.E","family":"van der Meulen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3881-4435","authenticated-orcid":false,"given":"P. W.","family":"Voorneveld","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5089-3677","authenticated-orcid":false,"given":"S. H. C.","family":"Veltkamp","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2636-303X","authenticated-orcid":false,"given":"A.A.","family":"van Bodegraven","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zuyderland Hospital  Sittard the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bodelier","sequence":"additional","affiliation":[{"name":"Amphia Hospital  Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-0381","authenticated-orcid":false,"given":"Z.","family":"Mujagic","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6981-6516","authenticated-orcid":false,"given":"M.","family":"Pierik","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6106-1470","authenticated-orcid":false,"given":"L. M. M.","family":"Verleye","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre  Maastricht the Netherlands"},{"name":"Radboud University Medical Centre  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4814-9376","authenticated-orcid":false,"given":"M.","family":"Duijvestein","sequence":"additional","affiliation":[{"name":"Radboud University Medical Centre  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6208-2967","authenticated-orcid":false,"given":"D. G.","family":"Bouwknegt","sequence":"additional","affiliation":[{"name":"University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-7677","authenticated-orcid":false,"given":"M. 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