{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:31:39Z","timestamp":1791955899220,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intraductal papillary mucinous neoplasms with low\u2010grade dysplasia (IPMNs w\/LGD) and benign cysts, including serous cystadenomas (SCAs), are common pancreatic cystic lesions (PCLs) that are better managed conservatively. The burden of patients who undergo surgical resection for these cysts is unknown. Our study aims to estimate the global prevalence of surgical resections for IPMNs w\/LGD and benign cysts, as well as the pre\u2010operative misclassification rate among all resected PCLs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the literature through September 2023 to identify full\u2010text articles that reported the surgical histopathology of resected PCLs. A proportional meta\u2010analysis was performed using a random\u2010effects model, with prevalence estimates reported as pooled proportions. Subgroup analysis and meta\u2010regression were performed based on use of endoscopic ultrasound (EUS), years of enrollment, and geographic location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05830) were identified. Among all surgically resected PCLs, 24% were IPMNs w\/LGD (95% CI: 18%\u201332%), 16% were SCAs (95% CI 13%\u201319%), 4% were other benign cysts (95% CI: 3%\u20136%), and 24% were pre\u2010operatively misclassified (95% CI: 16%\u201334%). Of the resected IPMNs, 62% had LGD (95% CI: 51%\u201371%). An increasing use of pre\u2010operative EUS is associated with a lower prevalence of resected SCAs (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) but has not impacted the rate of resections for IPMNs w\/LGD. The pre\u2010operative misclassification of PCLs has significantly decreased over time (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), although not significantly influenced by increasing EUS utilization or geographic location.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One quarter of PCLs are pre\u2010operatively misclassified and \u223c44% are surgically resected for benign cysts or IPMNs w\/LGD. Implementation of advanced diagnostic tools might improve pre\u2010operative classification and reduce overtreatment of PCLs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70145","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:21:00Z","timestamp":1764001260000},"source":"Crossref","is-referenced-by-count":6,"title":["High Burden of Pancreatic Surgery for Intraductal Papillary Mucinous Neoplasia With Low\u2010Grade Dysplasia and Benign Cysts: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1204-1550","authenticated-orcid":false,"given":"Samuel","family":"Tanner","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-9511","authenticated-orcid":false,"given":"Priyata","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Trinity Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elit","family":"Quingalahua","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Central Michigan University  Saginaw Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean M.","family":"Chalhoub","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Staten Island University Hospital Northwell Health  Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Hawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-2156","authenticated-orcid":false,"given":"Antonio","family":"Facciorusso","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Experimental Medicine Universit\u00e0 del Salento  Lecce Italy"},{"name":"Clinical Effectiveness Research Group University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Capurso","sequence":"additional","affiliation":[{"name":"Pancreato\u2010Biliary Endoscopy and Endosonography Division Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, and \u201cVita\u2010Salute\u201d San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6097-6414","authenticated-orcid":false,"given":"Un\u2010Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Office of Academic Affairs Northwell Health  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge D.","family":"Machicado","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CGH.2024.02.018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2017.07.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2018.14"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUTJNL\u20102018\u2010316027"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2023.12.009"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.014"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SURG.2023.07.016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SURG.2012.05.019"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PAN.2017.01.002"},{"key":"e_1_2_9_12_1","volume-title":"Covidence Systematic Review Software"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.N71"},{"key":"e_1_2_9_14_1","unstructured":"WellsG. 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