{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:03:33Z","timestamp":1779789813272,"version":"3.53.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ileal pouch\u2010anal anastomosis (IPAA) is a standard surgical procedure for ulcerative colitis (UC) and familial adenomatous polyposis. However, pouch\u2010related fistulae (PRF) are a significant complication. There is no consensus on the optimal treatment for PRF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated the effectiveness of autologous adipose tissue injection (AATI) as a treatment for PRF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010one patients with IPAA and a total of 29 PRF were treated with AATI. Patients who did not achieve healing after the first treatment were offered repeated injections. Patients were followed for a median of 16\u00a0months after AATI. Outcomes including clinical healing, treatment complications, and recurrence of PRF were registered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After a single treatment with AATI, 48% of the fistulae were clinically healed. Repeated treatments increased the healing rate to 69%. An additional 14% responded to AATI by reduced secretion from PRF. The procedure was well tolerated with minimal complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AATI appears to be a safe, minimally invasive, and sphincter\u2010saving treatment for PRF with promising healing rates. Further studies with larger cohorts are necessary to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70146","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T17:40:56Z","timestamp":1765820456000},"source":"Crossref","is-referenced-by-count":1,"title":["Autologous Adipose Tissue Injection as Treatment for Ileoanal Pouch\u2010Related Fistulae"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0592-3712","authenticated-orcid":false,"given":"Hayder","family":"Alqaisi","sequence":"first","affiliation":[{"name":"Department of Surgery Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Gastrointestinal Surgery Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Dige","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4963-1551","authenticated-orcid":false,"given":"Ole","family":"Thorlacius\u2010Ussing","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-3319","authenticated-orcid":false,"given":"Lilli","family":"Lundby","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6130.85"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjw209"},{"key":"e_1_2_11_4_1","first-page":"1678","volume-title":"Inflammatory Bowel Diseases","author":"Sherman J.","year":"2014"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz005"},{"key":"e_1_2_11_6_1","first-page":"342","volume-title":"Digestive and Liver Disease","author":"Pellino G.","year":"2023"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2007.04.009"},{"issue":"3","key":"e_1_2_11_8_1","first-page":"191","article-title":"Ileal Pouch Anal Anastomosis","volume":"26","author":"Govindasamy M.","year":"2013","journal-title":"Journal International Medical Sciences Academy"},{"issue":"10","key":"e_1_2_11_9_1","first-page":"571","article-title":"Complications Related to J\u2010Pouch Surgery","volume":"14","author":"Khan F.","year":"2018","journal-title":"Gastroenterology and Hepatology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjad051"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31203-X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-024-02963-x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjac172"},{"key":"e_1_2_11_14_1","volume":"184","author":"Dalby H. R.","year":"2022","journal-title":"Ugeskr L\u00e6ger"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.02.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002348"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002379"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.70146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ueg2.70146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.70146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T09:13:38Z","timestamp":1779786818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.70146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ueg2.70146"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.70146","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"article-number":"e70146"}}