{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:18:51Z","timestamp":1787818731186,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited data are available on the management and outcomes of postoperative Crohn's disease (CD) in older patients. We aimed to describe the management of CD in the postoperative setting and assess surgical postoperative recurrence (POR) in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a case\u2010control study including all adult patients with CD from the ENEIDA registry who had undergone a first intestinal resection with ileo\u2010colonic anastomosis. Patients were grouped according to their age at the time of the first surgery in older (over 60\u00a0years) subjects and controls (between 18 and 60\u00a0years of age).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 3982 (535 older subjects and 3454 controls) underwent a first intestinal resection for CD with an ileo\u2010colonic anastomosis. Time from CD diagnosis to surgery was significantly longer in older patients (114\u00a0\u00b1\u00a0128 vs. 93\u00a0\u00b1\u00a097\u00a0months;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Older patients also had a lower proportion of penetrating CD (25% vs. 39%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) and perianal disease (14% vs. 25%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). A significantly lower proportion of older patients started preventive therapies for POR (32% vs. 51%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). The cumulative risk of surgical POR was 3.2%, 5.3% and 10.1% in the older group and 3.6%, 6.6% and 14.2% in the control group at three, five and 10\u00a0years, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.093). In the multivariate logistic regression analysis, only prevention with thiopurines was associated with a lower risk of surgical POR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although postoperative preventive therapy with immunomodulators or biologicals is prescribed less often in older patients after a first intestinal resection, they develop surgical POR as often as younger adult patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70150","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T13:54:36Z","timestamp":1765029276000},"source":"Crossref","is-referenced-by-count":2,"title":["Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-2581","authenticated-orcid":false,"given":"M\u00edriam","family":"Ma\u00f1osa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital Universitari Germans Trias i Pujol  Badalona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-3792","authenticated-orcid":false,"given":"Margalida","family":"Calafat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitari Germans Trias i Pujol  Badalona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ricart","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Gastroenterology Hospital Cl\u00ednic de Barcelona IDIBAPS  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Nos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Reina Sof\u00eda IMIBIC Universidad de C\u00f3rdoba (UCO)  C\u00f3rdoba 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Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Gastroenterology Hospital General Universitario de Alicante ISABIAL  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Calvet","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Gastroenterology Hospital Universitari Parc Taul\u00ed de Sabadell Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT\u2010CERCA) Universitat Aut\u00f2noma de Barcelona  Sabadell 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III  Madrid Spain"},{"name":"Department of Gastroenterology Hospital Universitario de La Princesa Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa) Universidad Aut\u00f3noma de Madrid (UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Sicilia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Burgos  Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L\u00e1zaro","family":"P\u00e9rez\u2010Calle","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Alcorc\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Instituto de Salud Carlos III  Madrid 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