{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:51:03Z","timestamp":1791377463522,"version":"4.3.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic delta hepatitis represents a major health burden. Until recently, pegylated interferon\u2010alfa\u20102a (PEG\u2010IFN\u03b1) therapy was the only treatment option for patients infected with hepatitis D virus (HDV). The aim of this study was to evaluate 10\u2010year long\u2010term clinical and virological outcomes after 96\u00a0weeks of treatment with PEG\u2010IFN\u03b1 with or without tenofovir disoproxil fumarate (TDF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective follow\u2010up study of the Hep\u2010Net\u2010International\u2010Delta\u2010Hepatitis\u2010Intervention\u2010Study 2 (HIDIT\u2010II trial). Patients had received 96\u00a0weeks of treatment with either PEG\u2010IFN\u03b1\u20102a plus TDF or PEG\u2010IFN\u03b1\u20102a alone. Patients were included if they had completed the 96\u2010week treatment period and had at least one follow\u2010up visit (PEG\u2010IFN\u03b1\u20102a\u00a0+\u00a0TDF;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a051, PEG\u2010IFN\u03b1\u20102a alone;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a056).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients who received PEG\u2010IFN\u03b1\u20102a\u00a0+\u00a0TDF were younger (37 vs. 42\u00a0years) and no significant differences were observed in other baseline characteristics between the two treatment arms. A total of 26 patients (24%) developed one or more liver\u2010related endpoints after a mean time of 8.4\u00a0years. The incidence of endpoints was significantly lower in the combination group (14% vs. 34%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02). The development of liver\u2010related endpoints was also associated with non\u2010response to therapy (HDV RNA and HBsAg), elevated HBV DNA at week 72, and baseline age, cirrhosis, platelets, INR, AST, GGT, bilirubin and albumin according to the Cox regression model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The long\u2010term follow\u2010up of this large randomised clinical trial demonstrates that combination therapy with TDF and virological response to PEG\u2010IFN\u03b1\u20102a (undetectable HDV RNA and HBsAg loss) were associated with better clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>NCT00932971, EudraCT 2008\u2010005560\u201013<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70153","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T17:04:48Z","timestamp":1764435888000},"source":"Crossref","is-referenced-by-count":2,"title":["Ten\u2010Year Follow\u2010Up After 96\u00a0Weeks Treatment With Peginterferon Plus Tenofovir in Hepatitis D (HIDIT\u2010II): Improved Clinical Outcome After Combination Therapy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5419-7158","authenticated-orcid":false,"given":"Cihan","family":"Yurdaydin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Koc University Medical School  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-2134","authenticated-orcid":false,"given":"Julia","family":"Kahlh\u00f6fer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases und Endocrinology Hannover Medical School  Hannover Germany"},{"name":"HepNet Study\u2010House\/ German Liver Foundation  Hannover Germany"},{"name":"D\u2010SOLVE Consortium, an EU Horizon Europe Funded Project (No 101057917)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin Alexandru","family":"Caruntu","sequence":"additional","affiliation":[{"name":"Institutul National de Boli Infectioase \u201cProf Dr Matei Bals\u201d  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendal","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Dicle University Medical Faculty  Diyarbakir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"G\u00fcrel","sequence":"additional","affiliation":[{"name":"Uluda\u011f University Medical Faculty  Bursa 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Internal Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"German Center of Infection Research (DZIF) Hamburg\u2010L\u00fcbeck\u2010Borstel\u2010Riems  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3518-4060","authenticated-orcid":false,"given":"George V.","family":"Papatheodoridis","sequence":"additional","affiliation":[{"name":"First Department of Gastroenterology Medical School National and Kapodistrian University of Athens General Hospital of Athens \u201cLaiko\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Merle","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital of Heidelberg  Heidelberg 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