{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:03:33Z","timestamp":1779789813210,"version":"3.53.1"},"reference-count":95,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Study Aims<\/jats:title>\n                    <jats:p>Motorized spiral enteroscopy (MSE) was introduced as a major advancement in small\u2010bowel enteroscopy, enabling higher complete enteroscopy rates with shorter procedure times. However, after a fatal adverse event (AE) involving severe esophageal injury, the device was withdrawn from the market in July 2023. This raised questions about whether earlier safety signals were missed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta\u2010analysis comparing MSE with balloon\u2010based enteroscopy (double\u2010balloon [DBE] and single\u2010balloon enteroscopy [SBE], analyzed together). Outcomes included overall AEs, serious AEs (SAEs), and data collection quality. Results from the German PowerSpiral Registry were included, comprising 647 MSE procedures in 523 patients (January 2020\u2013July 2023) before registry closure following device withdrawal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen MSE studies (including the registry) and 55 DBE\/SBE studies were analyzed, totaling 12,559 enteroscopies (2024 MSE; 10,535 DBE\/SBE). MSE showed significantly higher rates of AEs (10.8% vs. 1.6%) and SAEs (1.5% vs. 0.4%). Procedure\u2010related SAEs were also more frequent with MSE (1.1% vs. 0.3%). Esophageal injury (0.10% vs. 0.009%) and intestinal perforation (0.5% vs. 0.1%) occurred more often with MSE, whereas acute pancreatitis (0.05% vs. 0.27%) and esophageal perforation (0% vs. 0.02%) were more common with DBE\/SBE. AE reporting for MSE was detailed, but structured follow\u2010up and reliable case tracking were inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MSE was associated with higher AE and SAE rates than balloon enteroscopy. These findings highlight the need for cautious adoption, rigorous safety monitoring, and more robust AE reporting when introducing innovative endoscopic technologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Registration<\/jats:title>\n                    <jats:p>The prospective and retrospective cohort studies were registered in the German Registry of Clinical Studies (DRKS), namely DRKS00026990 and DRKS00028571<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70165","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:23:57Z","timestamp":1767720237000},"source":"Crossref","is-referenced-by-count":0,"title":["Was Motorized Spiral Enteroscopy Too Risky? A Systematic Review and Meta\u2010Analysis Including German Registry Data"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9056-8844","authenticated-orcid":false,"given":"Ingo","family":"Steinbr\u00fcck","sequence":"first","affiliation":[{"name":"Department of Medicine and Gastroenterology Evangelisches Diakoniekrankenhaus Freiburg Academic Teaching Hospital University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-0700","authenticated-orcid":false,"given":"Armin","family":"Kuellmer","sequence":"additional","affiliation":[{"name":"Department of Medicine II Medical Center Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegbert","family":"Faiss","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sana Klinikum Lichtenberg Academic Teaching Hospital University of 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