{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:03:27Z","timestamp":1779789807210,"version":"3.53.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypomorphic variants of sucrase\u2010isomaltase (SI) have been associated with irritable bowel syndrome (IBS) in adults, but how their presence influences therapeutic outcomes is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the frequency of sucrase\u2010isomaltase hypomorphic variants in patients with IBS and their association with short\u2010 and long\u2010term outcomes after initiation of a FODMAP diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical outcomes in patients with IBS were retrospectively examined at mean 7.1 (range 2.5\u201313.4) years after being educated on a FODMAP diet by a gastrointestinal dietitian and their current food intake (Comprehensive Nutrition Assessment Questionnaire) and gastrointestinal symptoms were documented at interview. DNA extracted from whole blood samples was analysed with the Illumina Global Screening Array for sucrase\u2010isomaltase hypomorphic variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 72 participants (62% female, median age 59\u00a0years), 54% had at least one hypomorphic variant of which 85% were single\u2010carriers. On adjusted binary logistic regression analysis, no differences were noted across SI hypomorphic genotypic groups for retrospective analysis of initial response to a FODMAP diet or long\u2010term symptom control. Current dietary intakes of sucrose or starch were not different between non\u2010carriers and carriers, were directly related to FODMAP intake and did not differ in carriers according to adequacy of symptom control. Findings in those with diarrhoea\u2010predominant IBS (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a029) were similar to the those in the whole group. Too few double\u2010carriers (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06) precluded the definition of associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The presence of single sucrase\u2010isomaltase hypomorphic variants is common but was not associated with short\u2010 or long\u2010term outcomes or dietary intake for patients with IBS who were taught a FODMAP diet.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70173","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T16:36:01Z","timestamp":1768667761000},"source":"Crossref","is-referenced-by-count":0,"title":["The Associations of Sucrase\u2010Isomaltase Hypomorphic Variants With Long\u2010Term Outcomes and Dietary Intake in an Australian Irritable Bowel Syndrome Population Educated on the FODMAP Diet: A Cross\u2010Sectional and Retrospective Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4592-7809","authenticated-orcid":false,"given":"Hannah","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Eastern Health Clinical School Monash University  Melbourne Australia"},{"name":"Nutrition and Dietetics Department Northern Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-7481","authenticated-orcid":false,"given":"Tenghao","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Faculty of Science Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7535-1919","authenticated-orcid":false,"given":"Judi","family":"Porter","sequence":"additional","affiliation":[{"name":"School of Exercise &amp; Nutrition Sciences Institute for Physical Activity and Nutrition Deakin University  Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-8075","authenticated-orcid":false,"given":"Jacqueline","family":"Barrett","sequence":"additional","affiliation":[{"name":"Diet Solutions  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-3589","authenticated-orcid":false,"given":"Mayur","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health Clinical School Monash University  Melbourne Australia"},{"name":"Department of Gastroenterology Northern Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9108-1712","authenticated-orcid":false,"given":"Peter R.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology School of Translational Medicine Monash University and Alfred Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.70116"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14650"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.09.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176\u2010199507000\u201000001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102015\u2010308388"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.12.017"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010312456"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102019\u2010319411"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166523"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.06.063"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.01.047"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231891"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002852"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102018\u2010318036"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020416"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.01.242"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.10.040"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003374"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqz091"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2024.2377960"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000197173"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.46"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i24.7563"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010019\u201005780\u20107"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102036.1997.142318000.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2010.07.011"},{"issue":"1","key":"e_1_2_10_28_1","first-page":"5","article-title":"Predicting Basal Metabolic Rate, New Standards and Review of Previous Work","volume":"39","author":"Schofield W. 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