{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:03:15Z","timestamp":1779789795433,"version":"3.53.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although the current strategy in ulcerative colitis (UC) focuses on achieving endoscopic healing to improve long\u2010term outcomes, patients with persistent microscopic inflammation or intestinal barrier dysfunction remain at increased risk of relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We evaluated whether structural and functional abnormalities of the ileal and colonic mucosa assessed by probe\u2010based Confocal laser Endomicroscopy (pCLE) could predict the loss of therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The prospective single\u2010center study included 81 UC patients in clinical and endoscopic remission monitored for 24\u00a0months. At baseline, barrier dysfunction and histological inflammation (HI) were assessed through colonoscopy with pCLE and targeted biopsies from the terminal ileum, ascending colon, sigmoid, and rectum. Clinical evaluations were performed every 3\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The main predictors of loss of endoscopic remission were altered colonic permeability (Odds ratio OR\u00a0=\u00a03.85, 95% confidence interval CI 1.25\u201311.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.018) and HI detected by pCLE (OR\u00a0=\u00a06.04, 95% CI 1.89\u201319.31,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002). Survival analysis demonstrated an increased risk of clinical relapse in patients with an altered barrier in the terminal ileum (Hazard ratio HR\u00a0=\u00a06.01, 95% CI 3.08\u201316.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) or colon (HR\u00a0=\u00a06.51, 95% CI 2.08\u201317.21,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Persistent microscopic inflammation (Enhance index &gt; 1) was significantly associated with unfavorable clinical outcome (HR\u00a0=\u00a03.39, 95% CI 1.23\u20138.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.018). None of the 29 patients diagnosed with triple healing (histological healing associated with intact ileal and colonic permeability) at inclusion experienced relapse.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Morphological and functional evaluation using pCLE offers superior prognostic value and is emerging as a possible therapeutic target for the prevention of clinical and endoscopic relapses in UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70181","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:51:42Z","timestamp":1773373902000},"source":"Crossref","is-referenced-by-count":0,"title":["Integrated Assessment of Intestinal Barrier Function and Microscopic Inflammation Using Confocal Laser Endomicroscopy for Relapse Prediction in Ulcerative Colitis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7736-8140","authenticated-orcid":false,"given":"Horia","family":"Minea","sequence":"first","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7074-5938","authenticated-orcid":false,"given":"Catalin","family":"Sfarti","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"},{"name":"CENEMED Platform for Interdisciplinary Research \u201cGrigore T. Popa,\u201d University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-9236","authenticated-orcid":false,"given":"Stefan","family":"Chiriac","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-548X","authenticated-orcid":false,"given":"Ana\u2010Maria","family":"S\u00eengeap","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"},{"name":"CENEMED Platform for Interdisciplinary Research \u201cGrigore T. Popa,\u201d University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0194-7832","authenticated-orcid":false,"given":"Mihai","family":"Danciu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Department of Pathology \u201cSt. Spiridon\u201d University Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-6037","authenticated-orcid":false,"given":"Mihaela","family":"Blaj","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Department of Intensive Care \u201cSt. Spiridon\u201d University Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0609-3773","authenticated-orcid":false,"given":"Carmen Diana","family":"Cimpoesu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"CENEMED Platform for Interdisciplinary Research \u201cGrigore T. Popa,\u201d University of Medicine and Pharmacy  Iasi Romania"},{"name":"Department of Emergency Medicine \u201cSt. Spiridon\u201d University Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3487-9299","authenticated-orcid":false,"given":"Diana","family":"Iosep","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Department of Pathology \u201cSt. Spiridon\u201d University Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-5961","authenticated-orcid":false,"given":"Cristina","family":"Muzic\u0103","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-4940","authenticated-orcid":false,"given":"Gheorghe","family":"Balan","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0441-3980","authenticated-orcid":false,"given":"Sebastian","family":"Zenovia","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6956-6686","authenticated-orcid":false,"given":"Raluca","family":"Avram","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-0715","authenticated-orcid":false,"given":"Laura","family":"Huiban","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5001-4852","authenticated-orcid":false,"given":"Simona","family":"Juncu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-5520","authenticated-orcid":false,"given":"Anca","family":"Trifan","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"},{"name":"Institute of Gastroenterology and Hepatology \u201cSt. Spiridon\u201d Emergency Hospital  Iasi Romania"},{"name":"CENEMED Platform for Interdisciplinary Research \u201cGrigore T. Popa,\u201d University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i1.50"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad066"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000740"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jcag\/gwad034"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1102420"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.10.065"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.12.011"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjaa176"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.418"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010329964"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2021.1880892"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjaa110"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.02.035"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12756"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.09.046"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.043"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010331579"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.10.014"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14672"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102011\u2010300695"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjv131"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2025.02.009"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjaa255"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12714"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20100869\u20107619"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2022.2081453"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000437"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12436"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001681"},{"issue":"7","key":"e_1_2_14_32_1","first-page":"466","article-title":"Histologic Healing in Inflammatory Bowel Disease","volume":"18","author":"Christensen B.","year":"2022","journal-title":"Gastroenterology and Hepatology"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjaa056"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1221449"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16767"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i39.111353"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjaf200"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201068372\u20100"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.70181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ueg2.70181","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.70181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T09:10:53Z","timestamp":1779786653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.70181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ueg2.70181"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.70181","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"e70181"}}