{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:30:53Z","timestamp":1790220653999,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100022811","name":"Fondazione Nadia Valsecchi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022811","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Little is known about the genetic background of individuals with familial pancreatic cancer (PC). Integrating germline testing into surveillance may uncover previously unrecognized hereditary susceptibility and expand prevention strategies beyond\n                      <jats:italic>BRCA<\/jats:italic>\n                      testing alone. This study evaluated the genetic landscape of high\u2010risk individuals due to familiality (HRI\u2010FHs) enrolled in a national surveillance program.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five hundred HRI\u2010FHs from seven centers underwent surveillance and germline testing with a 41\u2010gene NGS panel. Pathogenic\/likely pathogenic variants (PGVs) and variants of unknown significance (VUS) were identified and correlated with clinical and imaging findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, forty\u2010four (8.8%) out of 500 HRI\u2010FHs carried at least one PGV, including 3.4% in high\u2010penetrance genes (\n                      <jats:italic>ATM, BRCA1\/2, PALB2, BRIP1<\/jats:italic>\n                      ). Notably, 8 out of 17 (47%) of\n                      <jats:italic>ATM<\/jats:italic>\n                      ,\n                      <jats:italic>BRCA1\/2, PALB2<\/jats:italic>\n                      carriers would not have met the national testing criteria based solely on their family history. An additional 5.4% (27\/500) carried PGVs in genes linked to other hereditary conditions (\n                      <jats:italic>CFTR, MUTYH, CTRC, SPINK1, APC<\/jats:italic>\n                      ), and 39.6% harbored at least one VUS. PGV status, age, and female gender were independent predictors of radiological abnormalities. Two PCs were diagnosed, both in mutation\u2010negative individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Integrating germline testing into surveillance redefines the management of familial PC. It uncovers hereditary susceptibility beyond classical criteria and supports cascade testing. PC also arises in mutation\u2010negative HRI. #NCT05724992.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70187","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T09:01:53Z","timestamp":1771146113000},"source":"Crossref","is-referenced-by-count":4,"title":["Discovering Hereditary Risk Through Surveillance: A Prospective Genetic Analysis of Individuals With Familial Pancreatic Cancer"],"prefix":"10.1002","volume":"14","author":[{"given":"Salvatore","family":"Paiella","sequence":"first","affiliation":[{"name":"University of Verona  Verona Italy"},{"name":"Pancreatic Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynecology University Hospital of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Secchettin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Paediatrics and Gynecology University of Verona  Verona 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