{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:01:01Z","timestamp":1792004461817,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Vedolizumab has become the preferred first\u2010line advanced therapy in ulcerative colitis (UC). However, the optimal second\u2010line treatment following vedolizumab failure remains unclear. We aimed to evaluate the effectiveness and safety of second\u2010line therapies after first\u2010line vedolizumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective study including UC patients from 31 centers who received infliximab (IFX), subcutaneous (SC) anti\u2010TNFs, or ustekinumab after vedolizumab failure. The primary endpoint was steroid\u2010free clinical remission (SFCR) at week 14. Predictors of remission were identified using multivariate logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 196 patients, 99 received IFX, 27 anti\u2010TNF SC, and 70 ustekinumab. At week 14, SFCR was achieved in 78 patients (39.8%): 38 (38.4%) with IFX, 8 (29.6%) with anti\u2010TNF SC, and 32 (45.7%) with ustekinumab, with no significant difference between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.32). Median treatment persistence ranged from 8 to 9.2\u00a0months. Baseline corticosteroid use was associated with lower odds of SFCR (OR\u00a0=\u00a00.37, 95% CI [0.18\u20130.73]). Adverse events occurred in 15.8% of patients, including 12.2% serious events. Overall adverse events were less frequent with ustekinumab than with IFX (10.0% vs. 24.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), while serious events were comparable (5.7% vs. 16.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.08). Discontinuation due to adverse events was more frequent with IFX (12.1%) and anti\u2010TNF SC (14.8%) than with ustekinumab (2.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.045 and 0.049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In UC patients failing vedolizumab, second\u2010line IFX, anti\u2010TNF SC, and ustekinumab showed similar effectiveness and persistence. Infliximab remains a robust option for rapid control in high inflammatory burden, whereas ustekinumab may be preferred for its superior safety profile in high\u2010risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70203","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:19:10Z","timestamp":1774459150000},"source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Second\u2010Line Advanced Therapy After Vedolizumab in Ulcerative Colitis: A Multicenter Cohort Study From the GETAID"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3368-5814","authenticated-orcid":false,"given":"Louis","family":"Calm\u00e9jane","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Reenaers","sequence":"additional","affiliation":[{"name":"Gastroenterology Department CHU Sart\u2010Tilman  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Gay","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU de Lyon Lyon\u2010Sud Hospital Pierre\u2010Benite, France and INSERM U1111\u2010CIRI  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Amiot","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology H\u00f4pitaux Universitaires Bic\u00eatre AP\u2010HP Universit\u00e9 Paris Saclay  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Nuzzo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology IBD and Intestinal Failure Intestinal Stroke Center AP\u2010HP H\u00f4pital Beaujon  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucine","family":"Vuitton","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Besancon University Hospital  Besancon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calina","family":"Atanasiu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology H\u00f4pital Saint\u2010Joseph  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Institut des MICI Clinique Ambroise Par\u00e9\u2010Hartmann  Neuilly\u2010sur\u2010Seine France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Altwegg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Guillo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University Hospital of Marseille Nord Assistance Publique\u2010H\u00f4pitaux de Marseille (AP\u2010HM) University of Aix\u2010Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Serrero","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University Hospital of Marseille Nord Assistance Publique\u2010H\u00f4pitaux de Marseille (AP\u2010HM) University of Aix\u2010Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Bouguen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU Rennes and University of Rennes INSERM, CIC1414 NUMECAN Institute  Rennes 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University Hospital UMR 1073 University of Rouen Normandy  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Benezech","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Centre Hospitalier Avignon  Avignon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryan","family":"Cavicchi","sequence":"additional","affiliation":[{"name":"Department of Gatroenterology Clinique de Bercy  Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeva","family":"Charkaoui","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Buisson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne Service d'H\u00e9pato\u2010Gastroent\u00e9rologie  Clermont\u2010Ferrand 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