{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:24:40Z","timestamp":1791991480936,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Upadacitinib (UPA) is the first oral Janus kinase (JAK) inhibitor approved for the treatment of Crohn's disease (CD). Real\u2010world data, particularly from large nationwide cohorts, remain limited. This study aimed to evaluate the real\u2010world effectiveness, safety, and treatment persistence of UPA in patients with CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter observational study including patients with CD who received UPA, using data from a nationwide registry. Patients were classified according to active luminal disease, extraintestinal manifestations (EIMs), or combination therapy with another biological therapy. Disease activity was assessed using the Harvey\u2013Bradshaw Index (HBI), C\u2010reactive protein (CRP), and fecal calprotectin (FC) at baseline and weeks 12, 24, and 52. Endoscopic outcomes were evaluated when available. Adverse events (AEs), hospitalizations, and treatment discontinuations were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>300 patients were included, representing a highly treatment\u2010refractory population, with 98% previously exposed to anti\u2010TNF agents and 59% to three or more advanced therapies. In those treated for active luminal disease, corticosteroid\u2010free clinical remission was achieved in 60%\u201362% of patients at weeks 12, 24 and 52. CRP normalization increased from 64% at week 12%\u201374% at week 52, while FC normalization improved from 48% to 64%. Patients treated for EIMs achieved high and sustained remission rates with excellent treatment persistence. Early remission at week 12 was strongly associated with sustained remission and meaningful endoscopic improvement. UPA was discontinued in 98 patients (39%). AEs were reported in 71 patients (24%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large real\u2010world cohort, UPA demonstrated sustained clinical and biochemical effectiveness, meaningful endoscopic response, and a safety profile consistent with clinical trial data. Early response emerged as a key predictor of long\u2010term outcomes, supporting the clinical utility of UPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70223","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:09:29Z","timestamp":1777536569000},"source":"Crossref","is-referenced-by-count":5,"title":["Real\u2010World Effectiveness and Safety of Upadacitinib in Crohn's Disease: Insights From the Eneida Registry"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-7581","authenticated-orcid":false,"given":"M.","family":"Iborra","sequence":"first","affiliation":[{"name":"Gastroenterology Department Inflammatory Bowel Disease Research Group Health Research Institute La Fe (IIS La Fe) IBD Unit La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Botella","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro Majadahonda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-0917","authenticated-orcid":false,"given":"M. D.","family":"Mart\u00edn\u2010Arranz","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Universidad Aut\u00f3noma de Madrid, Hospital La Paz Institute for Health Research La Paz Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ceballos","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Gran Canaria Dr. Negr\u00edn  Las Palmas de Gran Canaria Spain"},{"name":"Universidad de Las Palmas de Gran Canaria (ULPGC)  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mart\u00ednez\u2010Pascual","sequence":"additional","affiliation":[{"name":"Virgen de la Arrixaca University Hospital  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1299-9010","authenticated-orcid":false,"given":"A.","family":"Garrido","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Inflammatory Bowel Disease Research Group Health Research Institute La Fe (IIS La Fe) IBD Unit La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Varela","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Cabue\u00f1es  Gij\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Moreta","sequence":"additional","affiliation":[{"name":"Hospital Universitario R\u00edo Hortega de Valladolid  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8661-0608","authenticated-orcid":false,"given":"E.","family":"Brunet\u2010Mas","sequence":"additional","affiliation":[{"name":"Parc Taul\u00ed Hospital Universitari Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT\u2010CERCA)  Sabadell Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona CIBEREHD  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Gonz\u00e1lez\u2010Lama","sequence":"additional","affiliation":[{"name":"Hospital Doce de Octubre, Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Rodr\u00edguez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ntra. Sra. Candelaria  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vicu\u00f1a","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"J. P.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa) Universidad Aut\u00f3noma de Madrid (UAM). CIBEREHD  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-0340","authenticated-orcid":false,"given":"I.","family":"Ord\u00e1s","sequence":"additional","affiliation":[{"name":"IBD Unit Hospital Cl\u00ednic Barcelona  Barcelona Spain"},{"name":"IDIBAPS Barcelona, CIBEREHD  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3646-8919","authenticated-orcid":false,"given":"F.","family":"Arg\u00fcelles\u2010Arias","sequence":"additional","affiliation":[{"name":"University of Seville, Virgen Macarena Hospital  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tosca\u2010Cuquerella","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Universitari de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7605-3534","authenticated-orcid":false,"given":"R.","family":"Vicente\u2010Lid\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sierra\u2010Aus\u00edn","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Le\u00f3n  Le\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Rodr\u00edguez\u2010Lago","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Galdakao, Biobizkaia Health Research Institute  Galdakao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Mart\u00edn\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Infanta Cristina  Parla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-5458","authenticated-orcid":false,"given":"J. M.","family":"Paredes","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Peset  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sicilia","sequence":"additional","affiliation":[{"name":"Hospital de Burgos  Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Garc\u00eda de la Filia","sequence":"additional","affiliation":[{"name":"Hospital Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Elche  Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-1477","authenticated-orcid":false,"given":"M.","family":"Barreiro\u2010de Acosta","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario de Santiago de Compostela  Santiago de Compostela Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Betor\u00e9","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Jorge  Huesca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ferrer\u2010Bradley","sequence":"additional","affiliation":[{"name":"Hospital de Manises  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Garc\u00eda\u2010Alles","sequence":"additional","affiliation":[{"name":"Hospital de Sierrallana  Torrelavega Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-1262","authenticated-orcid":false,"given":"J. M.","family":"Huguet","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Castellet\u2010Farr\u00fas","sequence":"additional","affiliation":[{"name":"Hospital de Bellvitge  L'Hospitalet Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-7005","authenticated-orcid":false,"given":"M. J.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"},{"name":"Grupo de Investigaci\u00f3n Cl\u00ednica y Traslacional en Enfermedades Digestivas, Instituto de Investigaci\u00f3n Sanitaria Valdecilla (IDIVAL)  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-4139","authenticated-orcid":false,"given":"A.","family":"Guti\u00e9rrez\u2010Casbas","sequence":"additional","affiliation":[{"name":"Hospital General Dr Balmis  Alicante Spain"},{"name":"ISABIAL.CIBEREHD  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1.","family":"Ponferrada\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Hospital universitario Infanta Leonor  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-1742","authenticated-orcid":false,"given":"L.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Canarias  San Crist\u00f3bal de La Laguna Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-3792","authenticated-orcid":false,"given":"M.","family":"Calafat","sequence":"additional","affiliation":[{"name":"Hospital Universitari Germans Trias i Pujol  Badalona Spain"},{"name":"CIBEREHD  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Vera","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro Majadahonda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-3784","authenticated-orcid":false,"given":"C.","family":"Su\u00e1rez\u2010Ferrer","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Universidad Aut\u00f3noma de Madrid, Hospital La Paz Institute for Health Research La Paz Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fern\u00e1ndez\u2010Velado","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Gran Canaria Dr. Negr\u00edn  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rodr\u00edguez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of Murcia (IMIB)  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5825-1377","authenticated-orcid":false,"given":"A.","family":"M\u00ednguez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Inflammatory Bowel Disease Research Group Health Research Institute La Fe (IIS La Fe) IBD Unit La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-0144","authenticated-orcid":false,"given":"A.","family":"Mancebo","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Cabue\u00f1es  Gij\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Barrio","sequence":"additional","affiliation":[{"name":"Hospital Universitario R\u00edo Hortega  Valladolid Spain"},{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL)  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lario","sequence":"additional","affiliation":[{"name":"Parc Taul\u00ed Hospital Universitari Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT\u2010CERCA)  Sabadell Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona CIBEREHD  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"de La Cruz","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-207X","authenticated-orcid":false,"given":"Alejandro","family":"Hern\u00e1ndez\u2010Camba","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ntra. Sra. Candelaria  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3954-0736","authenticated-orcid":false,"given":"C.","family":"Rodr\u00edguez\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Navarra  Pamplona Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA)  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-4242","authenticated-orcid":false,"given":"M.","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa) Universidad Aut\u00f3noma de Madrid (UAM). CIBEREHD  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-1594","authenticated-orcid":false,"given":"E.","family":"Ricart","sequence":"additional","affiliation":[{"name":"IBD Unit Hospital Cl\u00ednic Barcelona  Barcelona Spain"},{"name":"IDIBAPS Barcelona, CIBEREHD  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7515-6805","authenticated-orcid":false,"given":"L.","family":"Almenara\u2010Michelena","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Balaguer","sequence":"additional","affiliation":[{"name":"Platform for Big Data, AI, Biostatistics &amp; Bioinformatics Health Research Institute La Fe (IIS La Fe)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-7196","authenticated-orcid":false,"given":"E.","family":"Dom\u00e8nech","sequence":"additional","affiliation":[{"name":"Hospital Universitari Germans Trias i Pujol  Badalona Spain"},{"name":"CIBEREHD  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6619-1511","authenticated-orcid":false,"given":"P.","family":"Nos","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Inflammatory Bowel Disease Research Group Health Research Institute La Fe (IIS La Fe) IBD Unit La Fe University and Polytechnic Hospital  Valencia Spain"},{"name":"Health Research Institute La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00311.2015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro\u20102023\u2010102400"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.047"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212728"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjaf138"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2025.01.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13010190"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.70073"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13247804"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.03.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro\u20102024\u2010102668"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003243"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast\u20102025\u2010001916"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjw168"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13083"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15958"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2020.05.007"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2025.0969"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otae060"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjac157"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjab232.032"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010024\u201005735\u2010w"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr5005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.02.017"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjae190.1180"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13688"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i15.2068"},{"issue":"5","key":"e_1_2_10_29_1","first-page":"251","article-title":"Advanced Combination Treatment with Biologic Agents and Novel Small Molecule Drugs for Inflammatory Bowel Disease","volume":"19","author":"Solitano V.","year":"2023","journal-title":"Gastroenterology & Hepatology (N Y)"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.03.034"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/qsy3kc"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izae105"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(22)00427\u20107"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i25.3182"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010023\u201001840\u20105"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2024.0798"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2455536"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2025.07.042"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.70223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ueg2.70223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.70223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:34:31Z","timestamp":1785339271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.70223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ueg2.70223"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.70223","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"article-number":"e70223"}}