{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:44:12Z","timestamp":1791495852857,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Disorders of gut\u2013brain interaction (DGBI) are highly prevalent worldwide. Although the epidemiology of DGBIs in Europe has been previously investigated, data comparing disease prevalence across European regions in relation to sociodemographic and lifestyle factors are lacking. Therefore, this study aimed to assess the prevalence, regional distribution, and associated factors of DGBI in Southern Europe, and to compare findings with other European regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were drawn from the Rome Foundation Global Epidemiology Study (RFGES). A representative sample of 20,420 European adults completed a comprehensive internet\u2010based questionnaire assessing DGBI presence, psychological distress, somatic symptoms, dietary habits, and healthcare utilization. Comparative analyses were conducted between Southern European countries and the rest of the continent (Northern, Western, and Eastern European countries). Multivariate logistic regression identified independent associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of adults with at least one DGBI was significantly higher in Southern Europe than in the rest of Europe (44.0% [42.4\u201345.5] vs. 39.0% [38.3\u201339.8];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Irritable bowel syndrome and functional dyspepsia were more prevalent in Southern Europe than in the rest of Europe. Similar trends were found for functional constipation and functional diarrhea. Individuals with DGBI in Southern Europe showed higher psychological distress but lower somatic symptom burden and lower work productivity and activity impairment. In multivariable models, residence in Southern Europe, female sex, younger age, higher psychological distress, greater somatic symptom burden, higher educational attainment, urban residence and more frequent healthcare utilization were independently associated with DGBI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Southern European populations exhibit a higher prevalence of DGBI compared with other European regions. Individuals with DGBI in Southern Europe showed higher rates of psychological distress, whereas those in the rest of Europe showed higher somatic symptom burden, greater work productivity and activity impairment. DGBI rates in Europe appear to be driven by a multifactorial interplay of demographic and psychosocial factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70226","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:20:58Z","timestamp":1777972858000},"source":"Crossref","is-referenced-by-count":2,"title":["Comparative Study on Burden, Features and Determinants of Disorders of Gut\u2010Brain Interaction Between Southern Europe and the Rest of Continent: Results From the Rome Foundation Global Epidemiology Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Giovanni","family":"Marasco","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-7274","authenticated-orcid":false,"given":"Keren","family":"Hod","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences School of Health Sciences Ariel University  Ariel Israel"},{"name":"Assuta Medical Centers  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Colecchia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami D.","family":"Sperber","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur S.","family":"Palsson","sequence":"additional","affiliation":[{"name":"Center for Functional GI &amp; Motility Disorders  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3111-0689","authenticated-orcid":false,"given":"Shrikant I.","family":"Bangdiwala","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods Evidence and Impact McMaster University  Hamilton Ontario Canada"},{"name":"Population Health Research Institute McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-0726","authenticated-orcid":false,"given":"Giovanni","family":"Barbara","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.14"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/UEG2.12259"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.DLD.2022.11.015"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2016.02.032"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.07.004"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.20517\/MRR.2021.12"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2018.07.011"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41575\u2010024\u201001033\u20109"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2020.04.014"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702005457"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.12.035"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/NMO.70079"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/APT.17791"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/MICROORGANISMS12101969"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.05.037"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12920\u2010024\u201001861\u20103"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/NMO.70060"},{"key":"e_1_2_14_19_1","doi-asserted-by":"crossref","unstructured":"The State of Food Security and Nutrition in the World 2022.The State of Food Security and Nutrition in the World 2022. 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