{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:01:19Z","timestamp":1786122079989,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Functional dyspepsia (FD) is characterised by postprandial fullness, early satiation, epigastric pain, or burning without structural abnormalities on upper endoscopy. Proton pump inhibitors (PPIs) are the preferred first\u2010line therapy. Given that the diagnosis of FD is largely based on symptom assessment, it remains unclear whether acid\u2010suppression meaningfully influences symptom presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This exploratory study aimed to determine the prevalence of acid\u2010suppressive therapy (PPIs or H2 receptor antagonists (H2RAs)) among FD patients and to compare symptom patterns between patients with and without these treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010centre, cross\u2010sectional observational study, ambulatory patients referred for diagnostic upper endoscopy completed the Waiting Room Questionnaire (WRQ). Endoscopic findings were recorded, and FD was defined using Rome IV. Acid\u2010suppression was defined as self\u2010reported use of PPIs or H2RAs. Symptom frequency was compared between patients on and off therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>1158 patients completed the WRQ; 27% fulfiled the criteria for FD. Among FD patients, 60% reported acid\u2010suppressive therapy, similar to patients with endoscopic findings. FD patients receiving acid\u2010suppression reported higher frequencies of early satiation (OR\u00a0=\u00a01.68, 95% CI 1.08\u20132.60), nausea (OR\u00a0=\u00a01.93, 95% CI 1.23\u20133.01), and epigastric pain (OR\u00a0=\u00a01.74, 95% CI 1.12\u20132.69). In subgroup analyses, therapy was associated with more frequent epigastric burning in postprandial distress syndrome (OR\u00a0=\u00a03.81, 95% CI 1.50\u20139.67) and higher frequencies of postprandial fullness (OR\u00a0=\u00a02.90, 95% CI 1.24\u20136.80) and early satiation (OR\u00a0=\u00a02.34, 95% CI 1.13\u20134.85) in the overlap subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FD is prevalent in open\u2010access endoscopy, and acid\u2010suppressive therapy is frequently used in this population. FD patients receiving acid\u2010suppression reported slightly higher frequencies of several symptoms, highlighting the need to further explore these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70247","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:29:19Z","timestamp":1783078159000},"source":"Crossref","is-referenced-by-count":0,"title":["The Associations Between Acid\u2010Suppressive Drug Intake and Symptom Profiles in Functional Dyspepsia Patients Referred for Open\u2010Access Endoscopy"],"prefix":"10.1002","volume":"14","author":[{"given":"Scheepers","family":"Janne","sequence":"first","affiliation":[{"name":"Neurosensitivity &amp; Motility TARGID KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-7904","authenticated-orcid":false,"given":"Carbone","family":"Florencia","sequence":"additional","affiliation":[{"name":"Neurosensitivity &amp; Motility TARGID KU Leuven  Leuven Belgium"},{"name":"Gastroenterology, UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheussen","family":"Hanne","sequence":"additional","affiliation":[{"name":"Neurosensitivity &amp; Motility TARGID KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van den Houte","family":"Karen","sequence":"additional","affiliation":[{"name":"Neurosensitivity &amp; Motility TARGID KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tack","family":"Jan","sequence":"additional","affiliation":[{"name":"Neurosensitivity &amp; Motility TARGID KU Leuven  Leuven Belgium"},{"name":"Gastroenterology, UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12355"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12061"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd011194.pub3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215469"},{"key":"e_1_2_8_8_1","unstructured":"RIZIV.Monitoring of Reimbursement Significant Expenses\u2014MORSE Rapport 2018 (Gegevens 2016) Detailanalyse van Enkele Geneesmiddelen Top 5 RIZIV Uitgaven Geneesmiddelen Voor Maagzuur en gastro\u2010oesofagale Reflux (2018)."},{"key":"e_1_2_8_9_1","unstructured":"B.Farrell K.Pottie W.Thompson et\u00a0al. 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