{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:02:08Z","timestamp":1786122128596,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2023\u201002079"],"award-info":[{"award-number":["2023\u201002079"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20220334"],"award-info":[{"award-number":["20220334"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fatty pancreas is a metabolically active ectopic fat depot, but its cardiometabolic implications have been assessed using heterogeneous thresholds. We investigated the association of fatty pancreas, quantified using MRI\u2010derived proton density fat fraction (PDFF) and categorised according to 2026 international consensus thresholds, with prevalent and incident type 2 diabetes (T2D), chronic kidney disease (CKD) and major adverse cardiovascular events (MACE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed 19,255 European\u2010ancestry participants from the UK Biobank imaging sub\u2010study. Pancreatic PDFF was categorised as normal (&lt;\u00a06%), mild (6 to &lt;\u00a016%) and moderate\u2010to\u2010severe fatty pancreas (\u2265\u00a016%). Outcomes were ascertained through national health records. Associations were estimated using multivariable logistic regression and Cox models, adjusted for age, sex, BMI\u2010defined obesity, elevated MRI\u2010derived visceral adipose tissue and outcome\u2010specific covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Moderate\u2010to\u2010severe fatty pancreas was associated with prevalent and incident T2D (OR 3.25, 95% CI 2.49\u20134.27;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; HR 2.72, 1.66\u20134.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), incident CKD (HR 1.82, 1.29\u20132.57;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and prevalent and incident MACE (OR 1.26, 1.04\u20131.56;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.022; HR 1.30, 1.02\u20131.66;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034). Mild fatty pancreas was associated with incident T2D (HR 2.19, 1.40\u20133.42;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and incident MACE (HR 1.29, 1.06\u20131.59;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.013). Each 5% increase in pancreatic PDFF was associated with higher odds and hazard of T2D (OR 1.16, 1.12\u20131.21; HR 1.17, 1.09\u20131.25; both\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fatty pancreas was independently associated with prevalent and incident T2D, incident CKD and, more modestly, with MACE. These findings position fatty pancreas within the cardiovascular\u2010kidney\u2010metabolic continuum and support the clinical relevance of consensus\u2010based PDFF thresholds for cardiometabolic risk assessment in European\u2010ancestry populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70253","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:56:46Z","timestamp":1783011406000},"source":"Crossref","is-referenced-by-count":0,"title":["Fatty Pancreas and Risk of Type 2 Diabetes, Chronic Kidney Disease and Cardiovascular Events: Evidence From a Population\u2010Based Cohort"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-1412","authenticated-orcid":false,"given":"Nicola","family":"Pugliese","sequence":"first","affiliation":[{"name":"Department of Medicine (H7), Centre for Reproduction, Metabolism and Molecular Medicine (CeRM) Karolinska Institutet  Huddinge 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and Health Professions Link Campus University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0941-3226","authenticated-orcid":false,"given":"Alessio","family":"Aghemo","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Hepatology Department of Gastroenterology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9168-4898","authenticated-orcid":false,"given":"Stefano","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Medicine (H7), Centre for Reproduction, Metabolism and Molecular Medicine (CeRM) Karolinska Institutet  Huddinge Sweden"},{"name":"Department of Molecular and Clinical Medicine University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Endocrinology Karolinska 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