{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:35:35Z","timestamp":1787164535401,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003197","name":"Agenzia Italiana del Farmaco, Ministero della Salute","doi-asserted-by":"publisher","award":["FARM6P824\u00a0B"],"award-info":[{"award-number":["FARM6P824\u00a0B"]}],"id":[{"id":"10.13039\/501100003197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The benefit of long\u2010term albumin (LTA) in improving survival and reducing complications in patients with cirrhosis and ascites is not consistently observed across studies, possibly reflecting differences in patient populations and treatment regimens. This study aimed to determine whether baseline serum albumin (SA) levels can predict which patients are most likely to benefit from LTA therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A post hoc analysis of the ANSWER trial was performed in 431 patients randomized to receive standard medical treatment (SMT) alone or SMT plus human albumin (SMT\u00a0+\u00a0HA). The interaction between baseline SA and LTA was investigated using competing\u2010risk survival analysis. The primary endpoint was 18\u2010month survival. Secondary endpoints included the incidence of cirrhosis\u2010related complications and hospitalizations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant treatment\u2010by\u2010albumin non\u2010linear interaction was found (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.010), indicating heterogeneity of treatment effect across baseline SA levels with the upper bound of the region of statistically demonstrable benefit occurring at approximately 3.2\u00a0g\/dL (sHR 0.53, 95% CI 0.28\u20130.99). In patients with SA \u2264\u00a03.2\u00a0g\/dL, 18\u2010month survival was significantly higher in the SMT\u00a0+\u00a0HA group compared with SMT alone (HR 0.47, 95% CI 0.29\u20130.77;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0021). No significant survival difference could be demonstrated in patients with SA &gt;\u00a03.2\u00a0g\/dL (HR 1.04, 95% CI 0.41\u20132.63;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.93). Regardless of baseline SA levels, LTA was associated with improved ascites control and reduced rates of complications and hospitalizations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LTA provides survival and morbidity benefits in patients with mild\u2010to\u2010moderate hypoalbuminemia, whereas in patients with normal SA levels, its benefit appears mainly limited to morbidity reduction. Baseline SA may therefore help in prioritizing LTA therapy when resources are constrained.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70258","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:42:38Z","timestamp":1783784558000},"source":"Crossref","is-referenced-by-count":1,"title":["Pre\u2010Treatment Serum Albumin Concentration Predicts Clinical Benefit of Long\u2010Term Albumin in Patients With Cirrhosis and Ascites"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-7027","authenticated-orcid":false,"given":"Enrico","family":"Pompili","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"},{"name":"Unit of Semeiotics, Liver and Alcohol\u2010related Diseases IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna 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