{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:56:54Z","timestamp":1790603814644,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n While portal hypertension (PH) typically resolves after liver transplantation (LT), persistence of PH may affect post\u2010transplant outcomes. We assessed the evolution of PH after LT and its impact on adverse outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We recorded clinical, laboratory, and imaging parameters of LT recipients between 2016 and 2022 in Vienna and Zagreb. Persistent features of CSPH were defined as the presence of portosystemic collaterals, platelet count (PLT) \u2264 110\u00a0G\/L, and\/or splenomegaly (\u2265 13\u00a0cm). PH\u2010related clinical events were defined as variceal bleeding, ascites requiring intervention, hepatic hydrothorax, portal vein thrombosis, or liver\u2010related death within 12\u00a0months post\u2010LT. Post\u2010LT outcomes were analyzed using landmark Cox regression for 3\u00a0months post\u2010LT.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 645 LT recipients (76% male, median age 59\u00a0years) listed with a median MELD of 15 points and PLT of 99\u00a0G\/L, features of CSPH were present in 537 (83.3%) at baseline. At year 1 after LT, MELD improved to 9 (IQR 7\u201312), PLT increased to 160\u00a0G\/L (IQR 120\u2013207), and features of CSPH persisted in 251\/453 classifiable patients (55.4%). PH events occurred in 75 (11.6%) and 84 (13%) deaths. In a landmark analysis from 3\u00a0months post\u2010LT (\n n<\/jats:italic>\n \u00a0=\u00a0521, 29 deaths), persistent thrombocytopenia (<\u00a0110\u00a0G\/L) at M3 independently predicted mortality (aHR 2.31, 95% CI 1.01\u20135.30,\n p<\/jats:italic>\n \u00a0=\u00a00.048) after adjustment for MELD, age, CRP, and pre\u2010LT TIPS.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n While PH improves after LT, features of CSPH persisted in 55% of classifiable patients and PH\u2010related clinical events occurred in 11.6% within the first year after LT. Persistent thrombocytopenia (< 110\u00a0G\/L) at 3\u00a0months post\u2010LT independently predicted post\u2010LT mortality (aHR 2.31, 95% CI 1.01\u20135.30,\n p<\/jats:italic>\n \u00a0=\u00a00.048).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ueg2.70268","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T18:46:37Z","timestamp":1786214797000},"source":"Crossref","is-referenced-by-count":0,"title":["Course of Portal Hypertension and Its Prognostic Impact After Liver Transplantation"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4615-915X","authenticated-orcid":false,"given":"Nina","family":"Dominik","sequence":"first","affiliation":[{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria"},{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Vienna Hepatic Hemodynamic Lab Medical University of Vienna Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-0821","authenticated-orcid":false,"given":"Petra","family":"Dinjar Kujundzic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Clinical Nutrition University Hospital Dubrava Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-5486","authenticated-orcid":false,"given":"Sandra","family":"Lovrekovic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology School of Medicine University Hospital Merkur University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9458-8970","authenticated-orcid":false,"given":"Hrvoje","family":"Premec","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology School of Medicine University Hospital Merkur University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Kristandl","sequence":"additional","affiliation":[{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-3061","authenticated-orcid":false,"given":"Lorenz","family":"Balcar","sequence":"additional","affiliation":[{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria"},{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Vienna Hepatic Hemodynamic Lab Medical University of Vienna Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-1013","authenticated-orcid":false,"given":"Maja","family":"Mijic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology School of Medicine University Hospital Merkur University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Lalovac","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology School of Medicine University Hospital Merkur University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-3372","authenticated-orcid":false,"given":"Benedikt Silvester","family":"Hofer","sequence":"additional","affiliation":[{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria"},{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Vienna Hepatic Hemodynamic Lab Medical University of Vienna Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-6120","authenticated-orcid":false,"given":"Lukas","family":"Hartl","sequence":"additional","affiliation":[{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria"},{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Vienna Hepatic Hemodynamic Lab Medical University of Vienna Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7504-8506","authenticated-orcid":false,"given":"Christian","family":"Sebesta","sequence":"additional","affiliation":[{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria"},{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Vienna Hepatic Hemodynamic Lab Medical University of Vienna Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1736-3699","authenticated-orcid":false,"given":"Georg","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria"},{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Vienna Hepatic Hemodynamic Lab Medical University of Vienna Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1618-476X","authenticated-orcid":false,"given":"Paul","family":"Th\u00f6ne","sequence":"additional","affiliation":[{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria"},{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Vienna Hepatic Hemodynamic Lab Medical University of Vienna Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2330-0017","authenticated-orcid":false,"given":"Mattias","family":"Mandorfer","sequence":"additional","affiliation":[{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria"},{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Vienna Hepatic Hemodynamic Lab Medical University of Vienna Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[{"name":"Department of Medicine III Division of Gastroenterology and Hepatology Medical University of Vienna Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danko","family":"Mikulic","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Transplantation University Hospital Merkur Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stipislav","family":"Jadrijevic","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Transplantation University Hospital Merkur Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-2876","authenticated-orcid":false,"given":"Georg","family":"Gy\u00f6ri","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Transplantation Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-7874","authenticated-orcid":false,"given":"Gabriela","family":"Berlakovich","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Transplantation Medical University of Vienna Vienna 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