{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:56:56Z","timestamp":1790603816007,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Laparoscopic cholecystectomy is the standard treatment for acute cholecystitis (AC), but some patients are unfit for (immediate) surgery. Endoscopic ultrasound\u2010guided gallbladder drainage (EUS\u2010GBD) using a lumen\u2010apposing metal stent (LAMS) is increasingly used in this population.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This multicenter cohort study aimed to evaluate practice patterns in EUS\u2010GBD across Western centers and to identify factors that influence outcomes.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n We retrospectively analyzed data from patients undergoing EUS\u2010GBD for AC across 18 centers. Patient\u2010related, procedural and outcome data were collected. The primary outcomes of interest were LAMS\u2010related adverse events (AEs), recurrent\u00a0biliary disease, recurrent acute cholecystitis, and all\u2010cause mortality. Time\u2010to\u2010event analyses were performed using center\u2010stratified Cox proportional hazards and Fine\u2013Gray competing\u2010risk models to identify LAMS procedural factors associated with clinical outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We included 496 patients with a median follow\u2010up of 176\u00a0days (IQR 44\u2013569). Technical and clinical success rates of EUS\u2010GBD were 98.2% and 93.5%, respectively. LAMS\u2010related AEs and recurrent biliary disease occurred in 11.1% and 18.8% of patients, respectively. Transduodenal access was associated with a lower cumulative incidence of LAMS\u2010related AEs compared with transgastric access (SHR 0.42, 95% CI 0.23\u20130.76,\n p<\/jats:italic>\n \u00a0=\u00a00.004) and lower rates of recurrent biliary disease and recurrent acute cholecystitis during follow\u2010up. Larger LAMS diameters (> 10\u00a0mm) were associated with a lower risk of recurrent acute cholecystitis and all\u2010cause mortality. No association between coaxial DPPS placement and improved long\u2010term outcomes could be demonstrated after competing\u2010risk adjustment. Among patients undergoing interval cholecystectomy (\n N<\/jats:italic>\n \u00a0=\u00a046), LAMS\u2010related conversion from laparoscopy to laparotomy occurred in 3 cases (6.5%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this large cohort study, transduodenal access route and choice of a large (> 10\u00a0mm) LAMS diameter were associated with improved outcomes of EUS\u2010GBD. EUS\u2010GBD may be a feasible option as a bridge to laparoscopic cholecystectomy, with limited risk of conversion to laparotomy. The findings of our study require prospective validation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ueg2.70275","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:32:28Z","timestamp":1786613548000},"source":"Crossref","is-referenced-by-count":0,"title":["EUS\u2010Guided Gallbladder Drainage for Acute Cholecystitis in the Western World: Heterogeneity in Current Practice and the Relation With Patient Outcome"],"prefix":"10.1002","volume":"14","author":[{"given":"Louis","family":"De Wispelaere","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hufkens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology UZ Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"van Malenstein","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology UZ Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0842-7813","authenticated-orcid":false,"given":"Wim","family":"Laleman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology UZ Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-5022","authenticated-orcid":false,"given":"Michiel","family":"Bronswijk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology UZ Leuven Leuven Belgium"},{"name":"Department of Gastroenterology and Hepatology Imelda Hospital Bonheiden Bonheiden Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9891-2686","authenticated-orcid":false,"given":"Schalk","family":"van der Merwe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology UZ Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Di Mitri","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit ARNAS Civico Hospital Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-7520","authenticated-orcid":false,"given":"Michele","family":"Amata","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit ARNAS Civico Hospital Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-7912","authenticated-orcid":false,"given":"Daniela","family":"Scimeca","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit ARNAS Civico Hospital Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9418-057X","authenticated-orcid":false,"given":"Niels G.","family":"Venneman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medisch Spectrum Twente Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1058-1323","authenticated-orcid":false,"given":"Koen R.","family":"Beukema","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medisch Spectrum Twente Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Larghi","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pelegrino","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Molinario","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7088-4414","authenticated-orcid":false,"given":"Dominiek","family":"De Wulf","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology AZ Delta Roeselare Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Devolder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology AZ Delta Roeselare Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3038-4669","authenticated-orcid":false,"given":"Dennis","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Interventional Endoscopy AdventHealth Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Arain","sequence":"additional","affiliation":[{"name":"Center for Interventional Endoscopy AdventHealth Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Cosgrove","sequence":"additional","affiliation":[{"name":"Center for Interventional Endoscopy AdventHealth Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad K.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Center for Interventional Endoscopy AdventHealth Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maham","family":"Hayat","sequence":"additional","affiliation":[{"name":"Center for Interventional Endoscopy AdventHealth Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kambiz","family":"Kadkhodayan","sequence":"additional","affiliation":[{"name":"Center for Interventional Endoscopy AdventHealth Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1601-1890","authenticated-orcid":false,"given":"Christophe","family":"Snauwaert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology AZ Sint\u2010Jan Bruges Bruges Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-9807","authenticated-orcid":false,"given":"Roberto","family":"Trasolini","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Vancouver General Hospital Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthuja","family":"Thilakanathan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Vancouver General Hospital Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-0619","authenticated-orcid":false,"given":"Shirley","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Vancouver General Hospital Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas G.","family":"Adler","sequence":"additional","affiliation":[{"name":"Center for Advanced Therapeutic Endoscopy Porter Adventist Hospital Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel S.","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Stony Brook University Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-019X","authenticated-orcid":false,"given":"Rogier P.","family":"Voermans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC University of Amsterdam Amsterdam the Netherlands"},{"name":"Cancer Center Amsterdam Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0423-9667","authenticated-orcid":false,"given":"Anouk G.","family":"Overdevest","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC University of Amsterdam Amsterdam the Netherlands"},{"name":"Cancer Center Amsterdam Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0477-4532","authenticated-orcid":false,"given":"Roy L. J.","family":"Van Wanrooij","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC University of Amsterdam Amsterdam the Netherlands"},{"name":"Cancer Center Amsterdam Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"P\u00e9rez\u2010Cuadrado\u2010Robles","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Georges\u2010Pompidou European Hospital APHP Centre University of Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-5242","authenticated-orcid":false,"given":"Willem J.","family":"Lammers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Jan de Jonge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco J.","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Degroote","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Brussels Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1895-0246","authenticated-orcid":false,"given":"Thomas","family":"Billiet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology AZ Groeninge Kortrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-1059","authenticated-orcid":false,"given":"Alexander","family":"Arlt","sequence":"additional","affiliation":[{"name":"Department for Internal Medicine and Gastroenterology University Hospital Klinikum Oldenburg A\u00f6R Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Diagnostic Center Bled Group Bled Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9840-8650","authenticated-orcid":false,"given":"Emine","family":"G\u00f6kce","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3684-5388","authenticated-orcid":false,"given":"Ellen","family":"Deschepper","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5949-2607","authenticated-orcid":false,"given":"Pieter","family":"Hindryckx","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.519"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102019\u2010319996"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/eus\u2010d\u201020\u201000130"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.04.238"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.08.052"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101717\u20101391"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2024.03.027"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.515"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2021.11.038"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0b013e3181b13ca2"},{"key":"e_1_2_10_13_1","first-page":"8","article-title":"A Package for Survival Analysis in R","volume":"3","author":"Therneau T.","year":"2024","journal-title":"R package version"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"e_1_2_10_15_1","unstructured":"D. D.SjobergandT.Fei \u201cTidycmprsk: Competing Risks Estimation \u201d R package version 1.1.1 2025 https:\/\/CRAN.R\u2010project.org\/package=tidycmprsk."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw341"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101738\u20106780"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v15.i9.574"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.12.026"},{"key":"e_1_2_10_20_1","article-title":"Lumen\u2010Apposing Stents With or Without Pigtail in endosonography\u2010guided Biliary Drainage for Malignant Distal Biliary Obstruction","author":"Sumalla\u2010Garcia A.","year":"2025","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/eus.eus_5_18"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010331245"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938\u2010025\u201000477\u20105"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/eus.0000000000000128"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000593"},{"key":"e_1_2_10_26_1","article-title":"Clinical Outcomes of EUS\u2010Guided Gallbladder Drainage in Patients With Acute Cholecystitis With \u2265 1 Year of Follow\u2010Up: A Systematic Review and meta\u2010analysis","author":"Canakis A.","year":"2025","journal-title":"Gastrointestinal Endoscopy"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102180\u20109817"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102495\u20105542"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.70275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ueg2.70275","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ueg2.70275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:14:37Z","timestamp":1790601277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ueg2.70275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/ueg2.70275"],"URL":"https:\/\/doi.org\/10.1002\/ueg2.70275","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"article-number":"e70275"}}