{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:56:57Z","timestamp":1790603817325,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The majority of irritable bowel syndrome (IBS) patients are diagnosed and managed in primary care, but this setting is underinvestigated to date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study aimed to improve our understanding of IBS in primary care by evaluating the clinical and psychosocial characteristics of affected patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a cross\u2010sectional post hoc analysis of the DOMINO study, which enrolled 483 adult IBS patients newly diagnosed by primary care physicians. We investigated baseline demographics and questionnaires assessing Rome IV criteria and stool pattern subtype, symptom severity (IBS\u2010SSS), quality of life (IBS\u2010QoL), somatic symptom disorder (PHQ\u201012), depression (PHQ\u20109) and anxiety (GAD\u20107).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>70% of the primary care diagnosed IBS patients fulfilled the Rome IV criteria (Rome+). The stool pattern subtype distribution according to the Rome IV diagnostic questionnaire was: 20% constipation (IBS\u2010C), 33% diarrhea (IBS\u2010D), 31% mixed (IBS\u2010M) and 16% unclassified (IBS\u2010U). Mean IBS\u2010SSS was 268\u00a0\u00b1\u00a098, with 46% and 36% of cases reporting moderate and severe IBS\u2010SSS, respectively. Rome\u00a0+\u00a0patients had, compared to Rome\u2212, a significantly higher IBS\u2010SSS, lower quality of life and higher psychosocial comorbidity. IBS\u2010M, IBS\u2010D and IBS\u2010C participants scored significantly higher on IBS\u2010SSS and IBS\u2010QoL than IBS\u2010U. Furthermore, IBS\u2010M had significantly higher somatic symptom disorder and depression and anxiety levels compared with IBS\u2010U.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The majority of primary care IBS patients fulfilled the Rome IV criteria, were subtyped as IBS\u2010D or IBS\u2010M and were characterised by moderate or severe IBS\u2010SSS. Rome+ and IBS\u2010M participants had higher symptom severity, lower quality of life and higher psychosocial comorbidity.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , Number NCT04270487.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70276","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:22:36Z","timestamp":1787912556000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Psychosocial Characteristics of Adult Primary Care IBS Patients: A Post hoc Analysis of the DOMINO Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Robbe","family":"Wils","sequence":"first","affiliation":[{"name":"TARGID (Translational Research Center for Gastrointestinal Disorders) KU Leuven  Leuven 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