{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:56:56Z","timestamp":1790603816059,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100025298","name":"Kenyon Review","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100025298","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011878","name":"Vlaamse regering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Globus is characterized by the sensation of a lump in the throat without dysphagia or underlying structural abnormality or major motility disorder. Reported prevalences vary considerably across studies. Globus has been linked to both heartburn and affective disorders. This study aims to determine the global prevalence of globus, its association with heartburn, overlap with disorders of gut\u2010brain interaction (DGBI) and psychosocial disorders, and its impact on health\u2010related quality of life (HRQOL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Internet surveys from the Rome Foundation Global Epidemiology study were used (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a054,127). Rome IV criteria were used to identify globus and concurrent DGBI. Heartburn was defined as symptoms \u2265 2\u20133\u00a0days\/week. Psychosocial co\u2010morbidity and somatic symptom severity were assessed with PHQ\u20104 and PHQ\u201015, and HRQOL by PROMIS\u201010.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The global prevalence of globus according to Rome IV criteria was 0.75%, representing 12.8% of esophageal DGBI and 1.86% of all DGBI. Prevalence was highest in Western Europe (0.94%) and Asia (0.90%), and lowest in the Middle East (0.31%). Globus was slightly more common in females (55.4%), and most affected individuals were aged between 40 and 64\u00a0years (46.6%). Coexisting heartburn was reported in 17.4% of cases, esophageal DGBI in 9.1%, and non\u2010esophageal DGBI in 49.0%. Anxiety and\/or depression was present in 60.5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Global prevalence of globus is 0.75%, with a slight female predominance, and is most prevalent below 65\u00a0years. Overlap with non\u2010esophageal DGBI was greater than with heartburn symptoms or esophageal DGBI, and most patients had anxiety and\/or depressive symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70277","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:32:07Z","timestamp":1787052727000},"source":"Crossref","is-referenced-by-count":0,"title":["Putting Globus Into Context: Prevalence, Characteristics, and Overlap With Other Disorders of Gut\u2010Brain Interaction"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0520-4734","authenticated-orcid":false,"given":"Karlien","family":"Raymenants","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders  KU Leuven Belgium"},{"name":"Department of Gastroenterology Neurogastroenterology &amp; Motility  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Van de Bruaene","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders  KU Leuven Belgium"},{"name":"Department of Gastroenterology Neurogastroenterology &amp; Motility  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-4583","authenticated-orcid":false,"given":"Sawangpong","family":"Jandee","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marthe","family":"Everaert","sequence":"additional","affiliation":[{"name":"Department of Neurosciences ExpORL Deglutology  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami D.","family":"Sperber","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur","family":"Palsson","sequence":"additional","affiliation":[{"name":"Center for Functional Gastrointestinal and Motility Disorders University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikant I.","family":"Bangdiwala","sequence":"additional","affiliation":[{"name":"Population Health Research Institute McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutaba","family":"Khatun","sequence":"additional","affiliation":[{"name":"Population Health Research Institute McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Rommel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Neurogastroenterology &amp; Motility  KU Leuven Belgium"},{"name":"Department of Neurosciences ExpORL Deglutology  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Vanuytsel","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders  KU Leuven Belgium"},{"name":"Department of Gastroenterology Neurogastroenterology &amp; Motility  KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders  KU Leuven Belgium"},{"name":"Department of Gastroenterology Neurogastroenterology &amp; Motility  KU Leuven Belgium"},{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"The Rome Foundation  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010002\u20100544\u20100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.012"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13850"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.221"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010017\u20100666\u2010x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529108996486"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016\u20105085(80)90142\u20100"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110000501"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000192173.00498.ba"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215100068687"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1982.00790590062017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2019.01.006"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751\u20102980.12354"},{"issue":"2","key":"e_1_2_11_15_1","first-page":"405","article-title":"Upper GIT Endoscopic Evaluation and Psychological State Assessment of Patients With Globus Sensation","volume":"28","author":"Khan M. 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