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Although this has been known for decades, the underlying mechanisms linking the two conditions remain unclear. We conducted a scoping review to evaluate the prevalence, clinical characteristics, diagnostic challenges and histopathological features of IgAD in patients with CeD. Thirty\u2010one studies published between 1985 and 2024 were included. IgAD was more prevalent among individuals with CeD, 1.4%\u20134.8% than in the general population, and CeD occurred in 5.9%\u201314.1% of patients with IgAD. Most patients presented with gastrointestinal symptoms, although selection bias was common. IgG\u2010based serology remains essential for diagnosis and monitoring, but its reliability during follow\u2010up is limited by the slow decline of antibodies. Histological findings indicate compensatory IgM and IgG responses and persistent mucosal immune activation. Improved strategies for diagnosis and long\u2010term monitoring of patients with both conditions are warranted.<\/jats:p>","DOI":"10.1002\/ueg2.70296","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:02:00Z","timestamp":1790859720000},"source":"Crossref","is-referenced-by-count":0,"title":["Immunoglobulin a Deficiency in Coeliac Disease: A Scoping Review"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9783-5192","authenticated-orcid":false,"given":"Kristine","family":"Bech","sequence":"first","affiliation":[{"name":"Hans Christian Andersen Children's Hospital University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-8843","authenticated-orcid":false,"given":"C\u00e6cilie","family":"Crawley","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Pediatrics and Adolescent Medicine Lillebaelt Hospital  Kolding Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-8816","authenticated-orcid":false,"given":"Rok Seon","family":"Choung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-9090","authenticated-orcid":false,"given":"Joseph A.","family":"Murray","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-2496","authenticated-orcid":false,"given":"Steffen","family":"Husby","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2826"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.345"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000002497"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010102119\u2010074236"},{"key":"e_1_2_11_7_1","unstructured":"W. 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