{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:40:52Z","timestamp":1792222852426,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007343","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Persistent gastrointestinal (GI) symptoms are frequently reported in patients with coeliac disease (CD). Knowledge about the role of disorders of gut\u2010brain interaction (DGBI) as the cause of these persistent symptoms remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the prevalence and factors associated with DGBI\u2010compatible symptom profiles in individuals with CD on a long\u2010term gluten\u2010free diet (GFD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult members of the Dutch Coeliac Society completed an online survey, including the Rome IV diagnostic questionnaire and validated questionnaires assessing psychological distress, non\u2010GI somatic symptom severity, and health\u2010related quality of life (QOL). Only individuals with CD adhering to a GFD \u2265\u00a01\u00a0year were included. A population\u2010based Dutch cohort served as the reference group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1001 participants with CD (79.3% female; median age 50\u00a0years), 64.8% met the criteria for \u2265\u00a01 DGBI\u2010compatible symptom profile compared with 31.3% in the reference group (for confounders adjusted odds ratio (AOR) 3.2 (95% CI 2.6\u20133.8)). Irritable bowel syndrome showed the strongest association with CD (AOR 4.5 (95% CI 3.3\u20136.2)). Having DGBI\u2010compatible symptom profiles was, like the reference group, associated with higher levels of psychological distress and non\u2010GI somatic symptom severity and lower health\u2010related QOL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Rome IV DGBI\u2010compatible symptom profiles are highly prevalent in individuals with CD on a long\u2010term GFD and are associated with impaired QOL. While ongoing gluten exposure and other comorbidities could not be excluded, these findings support the consideration of DGBI in the evaluation and treatment of persistent symptoms in patients with CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ueg2.70311","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:56:12Z","timestamp":1792220172000},"source":"Crossref","is-referenced-by-count":0,"title":["Symptom Profiles Compatible With Disorders of Gut\u2010Brain Interaction in Individuals With Coeliac Disease on a Long\u2010Term Gluten\u2010Free Diet"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2103-9491","authenticated-orcid":false,"given":"Tom","family":"van Gils","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg 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