{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:46:52Z","timestamp":1790174812094,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the performance of third\u2010trimester fetal biometry and fetal Doppler studies for the prediction of small\u2010for\u2010gestational\u2010age (SGA) neonates, and to explore contingency strategies using a first\u2010trimester prediction model based on maternal and fetal parameters and third\u2010trimester ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an observational cross\u2010sectional study of uncomplicated singleton pregnancies. Risk assessment for chromosomal abnormality was carried out in 4702 pregnancies using a combination of ultrasound markers (fetal nuchal translucency thickness (NT) and nasal bone assessment) and biochemistry (free beta\u2010human chorionic gonadotropin (\u03b2\u2010hCG) and pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A)) at 11 to 13 + 6 weeks. Maternal demographic characteristics and method of conception were recorded. Third\u2010trimester (30\u201334 weeks) fetal biometry (biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC) and femur length (FL)) and umbilical artery (UA) and middle cerebral artery Doppler studies were performed routinely in a subgroup (<jats:italic>n<\/jats:italic> = 2310). Reference ranges for birth weight were constructed using the cohort of 4702 women, and neonates were classified as small (SGA, \u2264 5th centile) or appropriate (AGA) for gestational age. First\u2010trimester, third\u2010trimester and integrated first\u2010 and third\u2010trimester prediction models for SGA were constructed using regression analysis and three different contingency strategies of rescanning in the third trimester were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the areas under the receiver\u2013operating characteristics curves (AUCs), AC (AUC = 0.85) and ultrasound\u2010estimated fetal weight (EFW, AUC = 0.87) were equally good predictors of SGA. The model was marginally improved by the addition of UA Doppler, smoking status and first\u2010trimester indices (free \u03b2\u2010hCG and PAPP\u2010A multiples of the median) (combined model, AUC = 0.88), but the difference was not statistically significant. A contingency strategy of rescanning 50% of the population in the third trimester according to the risk estimated by a first\u2010trimester prediction model yielded a detection rate of 79% for a 25% screen\u2010positive rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Third\u2010trimester ultrasound is effective in screening for SGA in uncomplicated pregnancies. The use of a contingency screening policy can reduce the need for unnecessary examinations. Copyright \u00a9 2012 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.10078","type":"journal-article","created":{"date-parts":[[2011,8,19]],"date-time":"2011-08-19T18:21:35Z","timestamp":1313778095000},"page":"535-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Performance of third\u2010trimester ultrasound for prediction of small\u2010for\u2010gestational\u2010age neonates and evaluation of contingency screening policies"],"prefix":"10.1002","volume":"39","author":[{"given":"A. 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