{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:35:11Z","timestamp":1781530511811,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,3,24]],"date-time":"2004-03-24T00:00:00Z","timestamp":1080086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"The Fetal Medicine Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In red blood cell (RBC) isoimmunized pregnancies fetal anemia is associated with a hyperdynamic circulation. The aim of the present study was to examine further the possible value of fetal middle cerebral artery peak systolic velocity (MCA\u2010PSV) in the management of affected pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A reference range of fetal MCA\u2010PSV with gestation was constructed from the study of 813 normal singleton pregnancies at 20\u201340 weeks' gestation. Fetal MCA\u2010PSV was also measured in 58 fetuses from RBC isoimmunized pregnancies, with maternal hemolytic antibody concentration of &gt;15 IU\/mL at 19\u201338 weeks' gestation and within 10 days of measurement of fetal hemoglobin concentration in blood obtained either by cordocentesis (<jats:italic>n<\/jats:italic> = 43) or at delivery (<jats:italic>n<\/jats:italic> = 15). In the RBC isoimmunized pregnancies each of the measured MCA\u2010PSV and hemoglobin concentrations was expressed as a delta value (difference in SDs from the normal mean for gestation). Regression analysis was used to determine the significance of the association between delta MCA\u2010PSV and delta fetal hemoglobin concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the normal pregnancies there was a significant increase in fetal MCA\u2010PSV with gestation (mean <jats:italic>MCA\u2010PSV<\/jats:italic> = 10<jats:sup>0.0223 \u00d7 <jats:italic>GA<\/jats:italic> + 0.963<\/jats:sup>). In RBC isoimmunized pregnancies the fetal MCA\u2010PSV was increased and there was a significant association between delta MCA\u2010PSV and delta hemoglobin concentration (delta hemoglobin = (delta MCA\u2010PSV + 0.093)\/\u22120.356; <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.638, <jats:italic>P<\/jats:italic> &lt; 0.0001). An MCA\u2010PSV of mean + 1.5 SDs detected 96% of severely anemic fetuses, with a hemoglobin deficit of at least 6 SDs, for a false\u2010positive rate of 14%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Measurement of fetal MCA\u2010PSV is a useful method of assessing fetal anemia. In the clinical management of isoimmunized pregnancies a cut\u2010off in MCA\u2010PSV of mean + 1.5 SDs can identify nearly all severely anemic fetuses with a low false\u2010positive rate. Copyright \u00a9 2004 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.1010","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T22:02:06Z","timestamp":1082066526000},"page":"432-436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Prediction of fetal anemia in rhesus disease by measurement of fetal middle cerebral artery peak systolic velocity"],"prefix":"10.1002","volume":"23","author":[{"given":"M.","family":"Scheier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hernandez\u2010Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Carmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Dezerega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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